用中性粒细胞与淋巴细胞比率和红细胞分布宽度辅助评估急性心肌梗死患者的左心室收缩功能

Q4 Medicine
B. J. Subhashchandra, R. Shivaswamy, S. Shreyas, H. S. Kiran
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引用次数: 0

摘要

摘要 动脉粥样硬化是一种多因素疾病,也是心血管疾病的主要病因,目前仍占全球死亡率的大部分。炎症在动脉粥样硬化的发生和发展过程中的作用已经明确,炎症的几种生物标志物可预测心血管风险。红细胞分布宽度(RDW)和中性粒细胞与淋巴细胞比值(NLR)是两种炎症标志物,可用于确定急性心肌梗死(AMI)患者的死亡风险和不良心血管预后。 研究急性心肌梗死患者左心室收缩功能与中性粒细胞-淋巴细胞比率、RDW和hs-CRP的关系。 对入院的急性心肌梗死-ST段抬高型心肌梗死(STEMI)患者进行了观察研究。入院时记录心电图(ECG),并抽血进行全血细胞图、hs-CRP、心肌酶和肾功能检测(RFT)。进行护理点超声心动图(ECHO)检查和初步经皮冠状动脉介入治疗(PCI)后超声心动图检查。 在一项涉及 100 名患者的研究中,患者的平均年龄为 57.61±13.151 岁。61至70岁年龄段的患者人数最多(33%),其次是51至60岁年龄段(22%)。研究中,男性占 76%。超声心动图显示,9%的患者射血分数正常,57%的患者有轻度左心室功能障碍,22%的患者有中度功能障碍,12%的患者有重度功能障碍。分析显示,在 STEMI 患者中,射血分数(EF)与 NLR(P < 0.001)以及 EF 与 RDW(P < 0.001)之间存在很强的负相关。但是,EF 和 hs-CRP 之间无明显相关性(P = 0.514)。 我们的研究结果表明,首次 STEMI 患者的 NLR 和 RDW 水平较高与左心室收缩功能障碍程度较高有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of Neutrophil-to-Lymphocyte Ratio and Red Cell Distribution Width as an Adjuvant in Assessing Left Ventricular Systolic Function in Patients with Acute Myocardial Infarction
ABSTRACT Atherosclerosis is a multifactorial disease and the major cause of cardiovascular disease that still accounts for most of the mortality worldwide. The role of inflammation in the development and progression of atherosclerosis has been clarified, and several biological markers of inflammation predict cardiovascular risk. Red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) are the two markers of inflammation that are used to determine risk of mortality and adverse cardiovascular outcomes in patients with acute myocardial infarction (AMI). To study the left ventricular systolic function in patients with AMI in relation to neutrophil to-lymphocyte ratio, RDW, and hs-CRP. An observational study was done on patients with AMI-ST-elevation myocardial infarction (STEMI) admitted to the hospital. On admission, Electrocardiogram (ECG) was noted, and blood was drawn for a complete hemogram, hs-CRP, cardiac enzymes, and renal function test (RFT). Point of care Echocardiography (ECHO) was obtained along with post-primary percutaneous coronary intervention (PCI) ECHO. In a study involving 100 patients, the mean age was 57.61 ± 13.151 years. The highest number of patients fell in the age group of 61 to 70 years (33%), followed by 51 to 60 years (22%). The study consisted of 76% males. Echocardiography revealed that 9% had normal ejection fraction, 57% had mild left ventricular dysfunction, 22% had moderate dysfunction, and 12% had severe dysfunction. Analysis showed that there is a strong negative correlation between ejection fraction (EF) and NLR (P < 0.001), as well as between EF and RDW (P < 0.001) in patients with STEMI. However, there was no significant correlation between EF and hs-CRP (P = 0.514). Our findings suggest that higher NLR and RDW levels, in patients with first STEMI are associated with higher degree of left ventricular systolic dysfunction.
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CiteScore
0.30
自引率
0.00%
发文量
221
审稿时长
43 weeks
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