非小细胞肺癌质子疗法剂量升级规划研究

IF 3.4 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2024-07-01 DOI:10.1016/j.phro.2024.100616

Arno C. Hessels, Sabine Visser, Stefan Both, Erik W. Korevaar, Johannes A. Langendijk, Robin Wijsman

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引用次数: 0

摘要

对于非小细胞肺癌（NSCLC），通过提高放疗剂量来改善局部控制可能会提高生存率。然而，一项基于光子的 RCT 显示，剂量升级组的危险器官剂量暴露增加，总生存率降低。本研究为20名NSCLC患者制定了针对原发肿瘤的剂量递增的强度调控质子治疗计划。对纵隔包膜进行了划定，以保留心脏周围的结构。原发肿瘤剂量可以增加到 74.0 Gy，而风险器官剂量和预计毒性不会显著增加。

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A planning study of proton therapy dose escalation for non-small cell lung cancer

In non-small-cell lung cancer (NSCLC), improving local control through radiotherapy dose escalation might improve survival. However, a photon-based RCT showed increased organ at risk dose exposure and worse overall survival in the dose escalation arm. In this study, intensity-modulated proton therapy plans with dose escalation to the primary tumour were created for 20 NSCLC patients. The mediastinal envelope was delineated to spare structures around the heart. It was possible to increase primary tumour dose up to 74.0 Gy without a significant increase in organ at risk doses and predicted toxicity.

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来源期刊

Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation

CiteScore

5.30

自引率

18.90%

发文量

审稿时长

6 weeks