肉毒杆菌毒素在异常运动治疗中的应用

Más Vita Pub Date : 2024-07-02 DOI:10.47606/acven/mv0235
María Gabriela González Chico, Xaviera Elizabeth Medina Godoy, Miliana Esperanza Estupiñan Bazurto, María José López Becerra
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引用次数: 0

摘要

导言:肉毒杆菌毒素对减少帕金森氏症等运动障碍后遗症至关重要。它能阻断肌肉收缩,提高生活质量,被用于美容和医疗治疗。研究方法采用非实验性纵向设计,在多个时间点对变量进行观察,不做任何操作。对 30 岁以上无帕金森病史的成年人采用了混合方法(定性和定量)。该研究采用严格的纳入和排除标准,纳入了来自 PubMed、Scopus 和 Scielo 的文献。目的评估肉毒杆菌毒素治疗帕金森症异常运动的疗效,并了解其长期效果。研究结果A 型肉毒杆菌毒素通过阻断乙酰胆碱减少震颤。它能改善帕金森氏症和本质性震颤的运动症状,但需要频繁和昂贵的治疗。有可能产生抗体,从而降低疗效。讨论:该疗法疗效显著,但其高昂的费用和频繁的治疗需求是其面临的挑战。患者在短期研究中表示满意,但还需要更多的长期研究。结论:虽然受成本和疗效持续时间的限制,但对运动障碍(尤其是帕金森氏症)的治疗前景广阔。未来的研究应寻求延长疗效并降低成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Botulinum Toxin in Treatments for Abnormal Movements
Introduction: Botulinum toxin is crucial for reducing sequelae in movement disorders such as Parkinson's. It blocks muscle contractions and improves quality of life, being used in both aesthetic and medical treatments. Methodology: A non-experimental longitudinal design was adopted, observing variables at multiple time points without manipulation. A mixed approach (qualitative and quantitative) was used with adults over 30 years old without Parkinson's history. The review included documents from PubMed, Scopus, and Scielo, applying rigorous inclusion and exclusion criteria. Objective: To evaluate the efficacy of botulinum toxin in treating abnormal movements in Parkinson's and understand its long-term effects. Results: Botulinum toxin type A reduces tremors by blocking acetylcholine. It improves motor symptoms of Parkinson's and essential tremor but requires frequent and costly treatments. There is a risk of developing antibodies that decrease its effectiveness. Discussion: It offers significant benefits, but its high cost and the need for frequent treatments are challenges. Patients report satisfaction in short-term studies, but more long-term research is needed. Conclusions: Promising for movement disorders, especially Parkinson's, although limited by cost and duration of effect. Future research should seek to extend therapeutic effects and reduce costs.
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