A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies

Background:

A meta-analysis research was implemented to appraise gingival wound healing management by photobiomodulation as adjunctive management to periodontal treatments.

Inclusive literature research till April 2023 was done and 908 interconnected researches were revised. Methods

The 9 picked researches, enclosed 517 periodontal disease persons were in the utilized researchers' starting point, 258 of them were utilizing photobiomodulation, and 259 were control. Odds ratio (OR) and 95% confidence intervals (CIs) were utilized to appraise the consequence of photobiomodulation in treating gingival wound healing by the dichotomous, and contentious approach and a fixed or random model.

Results:

Photobiomodulation had a significantly higher Landry wound healing index (MD, 0.87; 95% CI, 0.40-1.34, p<0.001), and complete wound epithelialization (OR, 6.47; 95% CI, 2.05-20.44, p=0.001) compared to the control of gingival wound healing in periodontal disease persons. However, photobiomodulation and control had no significant difference in the remaining wound area (MD, -10.03; 95% CI, -22.83-2.77, p=0.12) of gingival wound healing in periodontal disease persons.

Conclusions:

Photobiomodulation had a significantly higher Landry wound healing index, and complete wound epithelialization, however, no significant difference was found in the remaining wound area compared to control of gingival wound healing in periodontal disease persons. However, caution needs to be taken when interacting with its values since there was a low sample size of most of the chosen research found for the comparisons in the meta-analysis and a low number of chosen investigations for some of the comparisons.