{"title":"人间质干细胞(hMSCs)在胰腺损伤/癌症中的潜在用途","authors":"Havva Özgen Eyüpoğlu, Erol Eyüpoğlu, N. Serakinci","doi":"10.21926/obm.genet.2403252","DOIUrl":null,"url":null,"abstract":"Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication discusses current research findings on the application of hMSCs in pancreatic damage and cancer treatment while evaluating hMSC-mediated gene therapy in pancreatic disorders. Moreover, the challenges and considerations associated with hMSC-based therapies and the potential best therapeutic approaches are discussed. Furthermore, the current scientific evidence regarding hMSCs in revolutionizing the management of pancreatic damage and cancer, offering future perspectives for improved therapeutic strategies for patients facing these daunting conditions, is critically discussed.","PeriodicalId":503721,"journal":{"name":"OBM Genetics","volume":" 42","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/Cancer\",\"authors\":\"Havva Özgen Eyüpoğlu, Erol Eyüpoğlu, N. Serakinci\",\"doi\":\"10.21926/obm.genet.2403252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication discusses current research findings on the application of hMSCs in pancreatic damage and cancer treatment while evaluating hMSC-mediated gene therapy in pancreatic disorders. Moreover, the challenges and considerations associated with hMSC-based therapies and the potential best therapeutic approaches are discussed. Furthermore, the current scientific evidence regarding hMSCs in revolutionizing the management of pancreatic damage and cancer, offering future perspectives for improved therapeutic strategies for patients facing these daunting conditions, is critically discussed.\",\"PeriodicalId\":503721,\"journal\":{\"name\":\"OBM Genetics\",\"volume\":\" 42\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"OBM Genetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21926/obm.genet.2403252\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"OBM Genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21926/obm.genet.2403252","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/Cancer
Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication discusses current research findings on the application of hMSCs in pancreatic damage and cancer treatment while evaluating hMSC-mediated gene therapy in pancreatic disorders. Moreover, the challenges and considerations associated with hMSC-based therapies and the potential best therapeutic approaches are discussed. Furthermore, the current scientific evidence regarding hMSCs in revolutionizing the management of pancreatic damage and cancer, offering future perspectives for improved therapeutic strategies for patients facing these daunting conditions, is critically discussed.