急性冠状动脉综合征患者造影剂诱发肾病与血液高铁血红蛋白水平之间的关系

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Oya İmadoğlu, Ulaş Türker
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引用次数: 0

摘要

简介造影剂诱发的肾病(CIN)是一种先天性并发症,发生在接触造影剂的患者身上。研究目的我们旨在研究因急性冠状动脉综合征(ACS)而接受冠状动脉造影术(CAG)并接受或不接受原发性冠状动脉介入治疗的患者血液中高铁血红蛋白(MHb)水平与 CIN 发生之间的关系。患者和方法:在这项回顾性研究中,共纳入了 119 名确诊为 ACS 并接受冠状动脉造影术的患者。在术前和术后 1-3 小时内测量患者的 MHb 水平。造影剂暴露后 48 小时内血清肌酐水平比基线值增加≥0.3 mg/dL (26.5 µmol/L),或 7 天内血清肌酐水平比基线值增加 1.5-1.9 倍,即为 CIN。结果:CIN 阳性和 CIN 阴性患者与 MHb ≤%1 和 MHb >%1 患者之间的关系相似(P=0.4)。多变量逻辑回归分析显示,MHb值大于1并不能独立预测CIN的发生。两组患者在CAG前肌酐水平(P=0.02)、Mehran风险评分(<0.001)、血红蛋白水平(P=0.03)、是否存在低血压(P=0.03)、血液pH值(P=0.03)、左心室射血分数(LVEF)(<0.001)、是否存在糖尿病(P=0.014)、年龄(P=0.001)和吸烟史(P=0.02)方面存在显著差异。结论我们的研究表明,传统的风险因素会导致肾病。然而,血液中 MHb 水平的升高似乎并不会导致 ACS 患者发生 CIN。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between contrast-induced nephropathy and blood methemoglobin levels in acute coronary syndrome patients
Introduction: Contrast-induced nephropathy (CIN) is an iatrogenic complication occurring in patients exposed to contrast agents. Objectives: We aimed to investigate the relationship between blood methemoglobin (MHb) levels and the development of CIN in patients undergoing coronary angiography (CAG), with or without primary coronary intervention for acute coronary syndrome (ACS). Patients and Methods: In this retrospective study, 119 patients diagnosed with ACS who underwent coronary angiography were included. MHb levels were measured in patients before and at during the first 1 to 3 hours after the procedure. CIN was defined as an increase in serum creatinine levels by ≥0.3 mg/dL (26.5 µmol/L) from baseline within 48 hours after contrast exposure or an increase of 1.5-1.9 times the baseline value within 7 days. Results: The relationship between CIN-positive and CIN-negative patients and patients with MHb ≤%1 and MHb >% 1 was similar (P=0.4). Multivariate logistic regression analysis showed that an MHb value greater than 1 did not independently predict the development of CIN. Significant differences were observed between these two groups in terms of pre-CAG creatinine levels (P=0.02), Mehran risk score (<0.001), hemoglobin levels (P=0.03), the presence of hypotension (P=0.03), blood pH value (P=0.03), left ventricular ejection fraction (LVEF) (<0.001), the presence of diabetes mellitus (P=0.014), age (P=0.001), and smoking history (P=0.02). Conclusion: Our study demonstrates that traditional risk factors contribute to nephropathy. However, the increased blood MHb levels do not appear to contribute to the development of CIN in ACS patients.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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