弥漫性脑膜胶质细胞瘤的局部脑内形式--致痫性肿瘤的一个新实体?

V. Khalilov, A. N. Kislyakov, A. Kholin, U. A. Kukota, N. Medvedeva, A. S. Shapovalov, A. Druy
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引用次数: 0

摘要

弥漫性脑室胶质细胞瘤于2016年被引入世界卫生组织的中枢神经系统肿瘤分类。根据世界卫生组织于 2021 年制定的中枢神经系统肿瘤的实际分类,其可靠的验证需要结合特定的病理形态学和分子遗传学特征以及神经影像学数据。这些肿瘤通常发生在儿童和青少年中,其特点是沿神经轴广泛弥漫性脑膜播散,并表现出大量对比度增强的倾向,从而形成特殊的磁共振成像外观。尽管如此,而且这种肿瘤的发病率相当罕见,但一些出版物报道了越来越多的弥漫性脑膜胶质细胞瘤非典型病例,这表明这种肿瘤的临床表现、分子遗传学和放射学标准尚未完全揭示,需要进一步的全面研究。本文介绍了一名局灶性结构性癫痫患儿弥漫性脑膜胶质细胞瘤的复杂、跨学科诊断经验,以及非典型的放射学表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Local intracerebral form of diffuse leptomeningeal glioneuronal tumor – a new entity of the group of epileptogenic neoplasms?
Diffuse leptomeningeal glioneuronal tumor was introduced into the World Health Organization classification of central nervous system tumors in 2016. According to the actual World Health Organization classification of central nervous system tumors emerged in 2021, its reliable verification requires the combination of specific pathomorphological and molecular-genetic features as well as data of the neuroimaging. Typically occurring in children and adolescents these tumors are characterized by widespread diffuse leptomeningeal dissemination along the neuraxis and demonstrate a tendency to abundant contrast enhancement resulting in a specific magnetic resonance imaging appearance. Despite this, and the rather rare incidence, a number of publications have reported an increasing number of atypical cases of diffuse leptomeningeal glioneuronal tumor suggesting that the spectrum of clinical manifestations, molecular-genetic and radiological criteria of this tumor is not fully disclosed and requiring further comprehensive investigations. The article presents the experience of complex, interdisciplinary diagnosis of diffuse leptomeningeal glioneuronal tumor with atypical radiological picture in a child with focal structural epilepsy.
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