利用伏牛菌以生态友好的发菌方式合成氧化铁纳米粒子并揭示其作为抗生物膜和抗癌剂的潜力

Debasis Nayak, A. K. Mishra, Sasmita Malla, Umakanta Swain, Kalpana Panigrahi, Jibanjyoti Panda, Sarvesh Rustagi, P. R. Rauta, Y. K. Mohanta
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引用次数: 0

摘要

这项研究探索通过绿色化学,利用天然提取物而不是化学品来生产金属和金属氧化物纳米粒子,从而以生态友好的方式创造出功能性、生物相容性纳米材料。研究重点是利用伏牛花合成的氧化铁纳米粒子(GIONP),并对照传统的 IONPs(CIONP)评估其物理、化学和生物特性,包括抗癌能力。经紫外可见光谱和动态光散射证实,GIONP 具有更高的稳定性和一致的尺寸分布。通过铁扫描电子显微镜分析,它们还显示出更小的尺寸,而 X 射线衍射和傅立叶变换红外研究则验证了它们的晶体结构和有机官能团。值得注意的是,与 CIONPs 相比,GIONPs 具有很强的抗氧化性,对血细胞毒性低,有望用于静脉注射,对各种细菌菌株具有更强的抗菌和抗生物膜活性。研究显示,GIONPs 和 CIONPs 对 MDA-MB 231 癌细胞具有相似程度的毒性。普鲁士蓝检测法验证了 GIONPs 在这些细胞中的内化,处理后细胞内铁含量的增加也进一步证实了这一点。这些研究结果表明,GIONPs 不仅具有生物相容性和生态友好性,而且还包裹有生物活性化合物,它们的成功制备凸显了其在生物医学领域的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eco-Friendly Mycogenic Synthesis of Iron Oxide Nanoparticles Using Volvariella volvacea and Unveiling its Potential as Antibiofilm and Anticancer Agents
This research explores the eco-friendly creation of functional, biocompatible nanomaterials through green chemistry, utilizing natural extracts over chemicals to produce metal and metal oxide nanoparticles. The study focuses on iron oxide nanoparticles synthesized with Volvariella volvacea (GIONP) and evaluates their physical, chemical, and biological traits, including their anticancer capabilities, against traditionally made IONPs (CIONP). GIONPs, confirmed by UV-visible spectroscopy and dynamic light scattering, showed enhanced stability and consistent size distribution. They also demonstrated smaller sizes via Fe-scanning electron microscopy analysis, and X-ray diffraction and Fourier transform infrared studies verified their crystalline structure and organic functional groups. Notably, GIONPs exhibited strong antioxidant properties, low toxicity to blood cells, promising for intravenous use, and greater antimicrobial and antibiofilm activities against various bacterial strains than CIONPs. The study revealed that both GIONPs and CIONPs exhibit a similar degree of toxicity towards MDA-MB 231 cancer cells. The internalization of GIONPs within these cells was verified through a Prussian blue assay and further supported by the concentration-dependent increase in intracellular iron levels post-treatment. These findings underscore the successful formulation of GIONPs that are not only biocompatible and eco-friendly but also capped with bioactive compounds, highlighting their promising applications in the field of biomedicine.
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