接受头孢噻肟和氨苄西林治疗的母亲因胎膜早破引起的新生儿并发症:随机临床试验

IF 0.9 Q4 INFECTIOUS DISEASES
H. Boskabadi, Ali Najafi, N. Saghafi, Sayed J Sayedi, A. Moradi, M. Zakerihamidi
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引用次数: 0

摘要

胎膜早破(PROM)是导致早产和围产期死亡的最常见、最重要的原因之一。产妇的抗生素治疗会影响婴儿的预后。本研究旨在比较氨苄西林和头孢他啶对产妇新生儿预后的疗效。这项临床试验比较了头孢他啶和氨苄西林对 PROM 婴儿并发症的影响。220 名需要抗生素治疗的 PROM 孕妇被随机分为对照组(氨苄西林)和干预组(头孢他啶)两组。对产妇/胎儿在分娩前的状况以及婴儿在转入新生儿重症监护室、死亡或出院前的状况进行了跟踪调查。比较了两组婴儿的阿普加评分、心脏、呼吸和神经系统、感染、不成熟、窒息和死亡率。两组在以下方面差异显著:Apgar评分min1和min5、复苏需求、窒息、住院需求、感染和死亡率均有显著差异。对患有 PROM 的产妇使用头孢他啶可提高婴儿的 Apgar 评分,减少呼吸道并发症、感染、窒息、死亡率和重症监护室住院需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neonatal complications of premature rupture of membranes in mothers receiving cefotaxime and ampicillin: A randomized clinical trial
Premature rupture of membranes (PROM) is one of the most common and important causes of premature births and peripartum mortality. Maternal antibiotic treatment affects the infantile prognosis. This study was conducted to compare the efficacy of Ampicillin and Cefotaxime administered for the parturients on neonatal outcomes. A comparison between the effects of Cefotaxime and Ampicillin on infantile complications of PROM was done in this clinical trial. Two hundred and twenty parturients with PROM who needed antibiotic therapy were randomized in two groups of control (Ampicillin) and intervention (Cefotaxime) treatments. The maternal/fetal statuses up to accouchement and the infants’ status up to transfer to neonatal intensive care unit, death, or discharge from hospital were followed. The Apgar score, cardiac, respiratory and nervous systems, infection, immaturity, asphyxia, and mortality rates were compared in both groups. The differences between the two groups were significant in: Apgar score min1 and min5, need for resuscitation, asphyxia, need for hospitalization, infection, and mortality rate. Administration of Cefotaxime in parturients with PROM improved the Apgar scores and decreased respiratory complications, infection, asphyxia, mortality rate, and need for ICU hospitalization in infants.
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来源期刊
Journal of Infection Prevention
Journal of Infection Prevention Nursing-Advanced and Specialized Nursing
CiteScore
1.70
自引率
8.30%
发文量
46
期刊介绍: Journal of Infection Prevention is the professional publication of the Infection Prevention Society. The aim of the journal is to advance the evidence base in infection prevention and control, and to provide a publishing platform for all health professionals interested in this field of practice. Journal of Infection Prevention is a bi-monthly peer-reviewed publication containing a wide range of articles: ·Original primary research studies ·Qualitative and quantitative studies ·Reviews of the evidence on various topics ·Practice development project reports ·Guidelines for practice ·Case studies ·Overviews of infectious diseases and their causative organisms ·Audit and surveillance studies/projects
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