油杉叶纳米颗粒对丙烯酰胺诱导的成年雄性大鼠肝肾毒性的保护和治疗作用

A. Abduljalil, Kadry El-bakry, N. Omar, Lamiaa Elsayed Mokhtar Deef, Shereen A. Fahmy
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摘要

本研究调查了丙烯酰胺(ACR)对大鼠肝脏和肾脏的影响,以及油橄榄辣木(M. oleifera)叶纳米颗粒的潜在保护和治疗特性,并使用紫外可见光谱法创建和表征了银纳米颗粒。将 20 只成年雄性大鼠随机分为四组:对照组 (CT);丙烯酰胺组 (ACR):大鼠连续 3 周在饮用水中摄入 50 毫克/千克体重的丙烯酰胺;保护组 (Mo-NPs /ACR):大鼠连续 3 周每天摄入 50 毫克/千克体重的油橄榄叶纳米粒子 (Mo-NPs),并在饮用水中摄入 50 毫克/千克体重的丙烯酰胺。治疗组(ACR/Mo-NPs):每天给大鼠注射 50 毫克/千克体重的丙烯酰胺(ACR),连续 3 周,然后再注射油橄榄甲壳素纳米粒子(Mo-NPs),连续 3 周。研究人员采集了血液和组织样本进行生理和组织学研究,并使用彗星试验来确定 DNA 的损伤程度。服用 ACR 会增加 MDA、肌酐、尿素、谷丙转氨酶和谷草转氨酶的活性,同时降低 SOD 酶的活性。M. oleifera 纳米粒子处理可提高 SOD 酶活性,降低 ACR 对这些水平的破坏作用。用 M. oleifera 纳米粒子治疗 ACR 损伤的大鼠,其肝脏和肾脏的组织学异常有所改善。在 ACR 组的肝细胞中发现了更大的 DNA 损伤;不过,M. oleifera 纳米粒子可能修复了其他组的这种损伤。研究得出结论,M. oleifera 纳米粒子能增强保护作用,防止 ACR 对大鼠肝脏和肾脏功能的影响,这可能是由于它含有多种植物化学物质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective and Therapeutic Effects of Moringa oleifera Leave Nanoparticles against Acrylamide-Induced Hepato and Renal Toxicity in Adult Male Rats.
Atriplex species are tolerant to drought and salinity, therefore; they are appropriate for restoration The study investigated the effects of acrylamide (ACR) on the liver and kidneys in rats and the potential protective and therapeutic properties of Moringa oleifera (M. oleifera ) leaf nanoparticles, using UV-visible spectroscopy to create and characterize silver nanoparticles. 20 adult male rats were randomly divided into four groups: Control group (CT); Acrylamide group (ACR): rats received 50 mg/kg b.wt. in drinking water for 3 weeks; Protection group (Mo-NPs /ACR): rats received 50 mg/kg b.wt. of M. oleifera nanoparticles (Mo-NPs) daily for 3 weeks and were given 50 mg/kg b.wt. of acrylamide (ACR) daily for 3 weeks; Treatment group (ACR/Mo-NPs): rats were given 50 mg/kg b.wt. of acrylamide (ACR) for 3 weeks, followed by M. oleifera nanoparticles (Mo-NPs) for 3 weeks. Blood and tissue samples were obtained for the physiological and histological investigations, and a comet assay was used to determine the amount of DNA damage. Administration of ACR increased MDA, creatinine, urea, ALT, and AST activities while decreasing SOD enzyme activity. M. oleifera nanoparticle treatment raised SOD enzyme activity and decreased the damaging effects of ACR on these levels. Rats with ACR injuries treated with M. oleifera nanoparticles had improved histological abnormalities in their liver and kidneys. Greater DNA damage was seen in the liver cells of the ACR group; however, M. oleifera nanoparticles may have repaired this damage in other groups. The study concluded that M. oleifera nanoparticles provide enhanced protection against ACR's effects on liver and kidney function in rats, potentially due to its diverse phytochemicals.
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