高强度间歇运动对自体骨髓移植(BMT)中血小板移植的影响

Tayebe Zarekar, Abbas Hajifathali, S. Ahmadizad
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摘要

背景:血小板减少症是造血干细胞移植(HSCT)后的常见并发症。虽然输注血小板是治疗严重血小板减少症最常用的方法,但它也有公认的风险。高强度间歇运动(HIIE)会导致血小板减少。因此,本研究旨在通过运动增加血小板数量来减少血小板减少症。材料与方法:将 20 名淋巴瘤和多发性骨髓瘤患者分为高强度间歇运动组和对照组。为了确定最大运动能力,HIIE 组患者进行了分级运动测试。所有患者接受粒细胞集落刺激因子治疗 5 天,然后进行 HIIE 试验。在以峰值功率的 10% 至 20% 进行 5 分钟热身后,HIIE 组患者进行 HIIE 方案,包括以峰值功率的 20% 进行 12 次间隔为 1 分钟的 100%运动,中间穿插 1 分钟的主动休息。对照组患者在相同时间内坐着,不做任何体力活动。在试验前和试验后立即采集两次血液样本,并进行分析,以测量全血细胞计数。结果HIIE 组在血小板移植当天的血小板计数明显高于对照组(P=0.02)。HIIE 组的单次血小板输注量明显低于对照组(P=0.05)。结论根据本研究的结果,短时间的 HIIE 通过血小板减少对血小板移植有积极影响,并减少了血小板输注及其并发症,这可能是造血干细胞移植患者的一种有用策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of High Intensity Interval Exercise on Platelet Engraftment in Autologous Bone Marrow Transplantation (BMT)
Background: Thrombocytopenia is a frequent complication after hematopoietic stem cell transplantation (HSCT). Although platelet transfusion is the most used treatment for severe thrombocytopenia, it is associated with well-established risks. High-intensity interval exercise (HIIE) results in thrombocytosis. Therefore, this study aimed to reduce thrombocytopenia by increasing platelet count through exercise. Materials and Methods: Twenty lymphoma and multiple myeloma patients were divided into HIIE and control groups. To determine the maximal exercise capacity, patients in the HIIE group performed a graded exercise test. All patients received granulocyte colony-stimulating factor for 5 days, followed by a HIIE trial. After 5 min warm up at 10 to 20% of peak power, patients in the HIIE group performed an HIIE protocol that included 12 intervals of one-minute work at 100% peak power interspersed by one-minute active rest at 20% of peak power. Patients in the control group were seated for the same duration without any physical activity. Two blood samples were taken before and immediately after the trials and were analyzed for measuring complete blood count. Results: Platelet count on the day of platelet engraftment in the HIIE group was significantly higher than in the control group (P=0.02). Single-donor platelet transfusion was significantly lower in the HIIE group than in the control group (P=0.05). Conclusion: Based on the findings of the present study, a short bout of HIIE had a positive effect on platelet engraftment through thrombocytosis and reduced platelet transfusion and its complications, which could be a useful strategy for HSCT patients.  
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