膝关节神经源和神经通路及其与骨关节炎的致病联系和疼痛控制的影响

Ray Marks
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引用次数: 0

摘要

背景:目的:本文探讨是否有足够的理由相信膝关节神经网络中的一种或多种神经异常可能参与或牵连到至少某些形式的膝关节骨性关节炎的诱发和长期存在,但往往未被认识到,因而未得到治疗或被忽视:方法:研究了从多个来源检索到的同行评审数据,以强调和讨论膝关节神经的结构和功能性质及其在各种膝关节组织、脊髓和中枢神经系统以及运动控制通路中的影响:结果:膝关节神经通路受损或功能异常会影响正常的关节生物力学和关节稳定性,从而影响膝关节病变的发生或延续以及疼痛纤维和认知的过度激活:为了提高旨在避免膝关节骨关节炎疼痛和残疾的策略的有效性,应关注其可能持续存在的神经病理学,以及易受伤害的老年人在关节保护、感知和稳定性机制方面可能出现的衰退。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Knee Joint Neural Sources and Pathways and Their Osteoarthritis Pathogenic Linkages and Pain Control Implications
Background: Knee joint osteoarthritis, a widespread disabling disease with no known cause continues to produce considerable bouts of intractable pain and disability as a result of multiple disease associated health problems despite years of research. Aim: This paper examines if there is sufficient reason to believe one or more neural based abnormalities in the knee neural network may be involved or implicated in inducing and perpetuating at least some forms of knee joint osteoarthritis, but is often unrecognized and thus untreated or ignored. Methods: Peer reviewed data retrieved from several sources were examined to highlight and discuss the structural and functional nature of the knee joint nerves and their ramifications in various knee joint tissues, the spinal cord and central nervous system and motor control pathways. Results: Knee joint nerve pathways that are damaged or functioning abnormally can affect normal joint biomechanics, plus joint stability and thereby can influence the onset or perpetuation of knee joint pathology and exaggerated activation of pain fibers and cognitions. Conclusion: To improve the effectiveness of strategies designed to avert knee joint osteoarthritis pain and disability, attention to its possible ongoing neuropathology as well as possible declines in joint protective, perceptual and stability mechanisms in older vulnerable adults are indicated.
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