Qingyan Wang, Wei Sun, Wenjie Chen, Ruiping Li, Hongxi Xu, S. Okyere, Jun Jiang
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引用次数: 0
摘要
玉米赤霉烯酮(ZEN)是一种霉菌毒素,通常存在于发霉的谷物中。玉米赤霉烯酮通过干扰卵泡和胚胎发育、降低精子活力和破坏内源性激素的平衡,对家畜造成生殖毒性,导致流产、卵巢功能障碍和死胎等生殖系统疾病。玉米赤霉烯酮对生殖系统的损害主要归因于以下因素:(1)与雌激素受体相互作用;(2)诱导氧化应激;(3)诱导细胞凋亡、坏死、自噬和铁脱落;(4)干扰细胞复制周期。天然化合物和微量营养素有可能减轻 ZEN 造成的氧化应激。此外,一些微生物和酶也显示出良好的解毒效果。因此,在这篇综述中,我们重点探讨了 ZEN 对动物配子发育和胚胎发育造成的损害、其分子机制,并提出了一些预防 ZEN 引起的毒性的潜在缓解措施,从而为预防与 ZEN 相关的毒性提供信息,并为进一步开发治疗 ZEN 引起的损害的候选药物奠定基础。
Reproductive Toxicity Caused by Zearalenone on Animals and Its Possible Interventions
Zearalenone (ZEN) is a mycotoxin that is usually found in moldy grains. ZEN causes reproductive toxicity to domestic animals by interfering with follicular and embryonic development, reducing sperm vitalityand destroying the homeostasis of endogenous hormones, leading to reproductive system diseases such as abortion, ovarian dysfunctionand stillbirth. The reproductive damage caused by zearalenone is mainly attributed to the factors as follows: (1) interaction with estrogen receptor; (2) induction of oxidative stress; (3) induction of apoptosis, necrosis, autophagyand iron prolapse and (4) interference with cell replication cycle. Natural compounds and micro-nutrients have the potential to alleviate the oxidative stress caused by ZEN. In addition, some microorganisms and enzymes have also shown good detoxification effects. Therefore, in this review, we focus on the damage caused by ZEN on animal gamete development and embryonic development, its molecular mechanismsand suggested some potential mitigation measures for the prevention of ZEN-induced toxicity to provide information for preventing toxicity associated with ZEN as well as serve as a foundation for further development of drug candidates for the treatment of ZEN induced damage.