{"title":"昼夜节律失调与视网膜变性和阿尔茨海默病的关系：特别关注穆勒神经胶质细胞","authors":"Glori Das, Thomas E. Milner","doi":"10.3389/fphot.2024.1389683","DOIUrl":null,"url":null,"abstract":"This review examines circadian dysregulation and the role of Müller glial cells (MGCs) in retinal degeneration associated with Alzheimer’s disease (AD). Evidence supporting the interdependence of circadian rhythm (CR) disruption and AD progression is presented. Also reviweed are reports substantiating the role of MGCs in maintaining CR. Studies documenting MGC dysfunction in AD retinas suggest that gliosis, altered diurnal patterns in water homeostasis, blood-retina barrier breakdown, and impaired ocular glymphatic clearance are relevant to disease progression. Similarities between AD and various retinopathies are explored with respect to MGC physiology and CR dysfunction. We propose that MGC circadian dysregulation is diagnostically and therapeutically relevant to AD retinopathy.","PeriodicalId":73099,"journal":{"name":"Frontiers in photonics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of circadian dysregulation with retinal degeneration and Alzheimer’s disease: a special focus on Muller glial cells\",\"authors\":\"Glori Das, Thomas E. Milner\",\"doi\":\"10.3389/fphot.2024.1389683\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review examines circadian dysregulation and the role of Müller glial cells (MGCs) in retinal degeneration associated with Alzheimer’s disease (AD). Evidence supporting the interdependence of circadian rhythm (CR) disruption and AD progression is presented. Also reviweed are reports substantiating the role of MGCs in maintaining CR. Studies documenting MGC dysfunction in AD retinas suggest that gliosis, altered diurnal patterns in water homeostasis, blood-retina barrier breakdown, and impaired ocular glymphatic clearance are relevant to disease progression. Similarities between AD and various retinopathies are explored with respect to MGC physiology and CR dysfunction. We propose that MGC circadian dysregulation is diagnostically and therapeutically relevant to AD retinopathy.\",\"PeriodicalId\":73099,\"journal\":{\"name\":\"Frontiers in photonics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in photonics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fphot.2024.1389683\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in photonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fphot.2024.1389683","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
这篇综述探讨了昼夜节律失调以及Müller神经胶质细胞（MGCs）在与阿尔茨海默病（AD）相关的视网膜退化中的作用。有证据表明，昼夜节律（CR）紊乱与阿尔茨海默病的发展相互依存。报告还证实了 MGCs 在维持昼夜节律中的作用。记录了AD视网膜中MGC功能障碍的研究表明，神经胶质增生、水稳态的昼夜模式改变、血液-视网膜屏障破坏以及眼部血糖清除功能受损与疾病进展有关。我们探讨了 AD 与各种视网膜病变之间在 MGC 生理和 CR 功能障碍方面的相似性。我们提出，MGC昼夜节律失调在诊断和治疗上与AD视网膜病变有关。
Association of circadian dysregulation with retinal degeneration and Alzheimer’s disease: a special focus on Muller glial cells
This review examines circadian dysregulation and the role of Müller glial cells (MGCs) in retinal degeneration associated with Alzheimer’s disease (AD). Evidence supporting the interdependence of circadian rhythm (CR) disruption and AD progression is presented. Also reviweed are reports substantiating the role of MGCs in maintaining CR. Studies documenting MGC dysfunction in AD retinas suggest that gliosis, altered diurnal patterns in water homeostasis, blood-retina barrier breakdown, and impaired ocular glymphatic clearance are relevant to disease progression. Similarities between AD and various retinopathies are explored with respect to MGC physiology and CR dysfunction. We propose that MGC circadian dysregulation is diagnostically and therapeutically relevant to AD retinopathy.
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