使用伊赛珠单抗后银屑病关节炎患者的前庭神经炎得到改善

Sherry Ershadi, Shivkar Amara, M. Lebwohl
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引用次数: 0

摘要

银屑病关节炎(PsA)是一种慢性炎症,通常会影响外周关节和皮肤。最近的研究表明,PsA 与前庭耳蜗功能障碍之间存在关联。在此,我们介绍了一例 43 岁男性患者的病例,该患者有控制性银屑病(Pso)和 PsA 病史,突发严重眩晕、恶心和呕吐。诊断评估排除了中枢性病因,诊断为不明原因的前庭神经炎。尽管使用常规药物治疗效果甚微,但患者在使用ixekizumab(一种用于治疗PsA和Pso的IL-17抑制剂)治疗后,眩晕症状明显缓解。本病例强调了生物制剂对与 PsA 相关的前庭功能障碍的潜在治疗效果。该领域的未来研究可能会为 PsA 患者前庭症状的新型治疗策略提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improvement of Vestibular Neuritis in a Patient with Psoriatic Arthritis following Ixekizumab Administration
Psoriatic arthritis (PsA) is a chronic inflammatory condition commonly affecting peripheral joints and the skin. Recent studies have shown an association between PsA and vestibulocochlear dysfunction. Here, we present the case of a 43 year-old male with a history of controlled psoriasis (Pso) and PsA who presented with sudden-onset severe vertigo, nausea, and vomiting. Diagnostic evaluation ruled out a central etiology, leading to a diagnosis of vestibular neuritis of unknown origin. Despite minimal improvement with conventional medications, the patient experienced significant relief from vertigo symptoms following treatment with ixekizumab, an IL-17 inhibitor used to manage his PsA and Pso. This case highlights a potential therapeutic effect of biological agents on vestibular dysfunction associated with PsA. Future research in this area may provide insights into novel treatment strategies for vestibular symptoms in patients with PsA. 
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