含三唑嘌呤的吡啶鎓分子的合成

Molbank Pub Date : 2024-07-24 DOI:10.3390/m1855
Aleksejs Burcevs, M. Turks, Irina Novosjolova
{"title":"含三唑嘌呤的吡啶鎓分子的合成","authors":"Aleksejs Burcevs, M. Turks, Irina Novosjolova","doi":"10.3390/m1855","DOIUrl":null,"url":null,"abstract":"Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives in water. Target structures were obtained using the tosylation of hydroxyl groups of 2-(6-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2-(piperidin-1-yl)-9H-purin-9-yl)propane-1,3-diol, the subsequent introduction of pyridine, and ion exchange. The compounds were characterized using 1H- and 13C-NMR spectra, FTIR, UV–Vis, and HRMS data.","PeriodicalId":509184,"journal":{"name":"Molbank","volume":"20 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of Pyridinium Moiety Containing Triazolyl Purines\",\"authors\":\"Aleksejs Burcevs, M. Turks, Irina Novosjolova\",\"doi\":\"10.3390/m1855\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives in water. Target structures were obtained using the tosylation of hydroxyl groups of 2-(6-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2-(piperidin-1-yl)-9H-purin-9-yl)propane-1,3-diol, the subsequent introduction of pyridine, and ion exchange. The compounds were characterized using 1H- and 13C-NMR spectra, FTIR, UV–Vis, and HRMS data.\",\"PeriodicalId\":509184,\"journal\":{\"name\":\"Molbank\",\"volume\":\"20 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molbank\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/m1855\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molbank","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/m1855","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

通过在嘌呤 N(9)位的丙烷-1,3-二醇片段中引入吡啶基,获得了 2-哌啶基-6-三唑基嘌呤衍生物的吡啶盐,从而提高了 2-氨基-6-三唑基嘌呤衍生物在水中的溶解度。通过对 2-(6-(4-(4-甲氧基苯基)-1H-1,2,3-三唑-1-基)-2-(哌啶-1-基)-9H-嘌呤-9-基)丙烷-1,3-二醇的羟基进行对甲苯磺酰化、随后引入吡啶和离子交换,获得了目标结构。利用 1H 和 13C-NMR 光谱、傅立叶变换红外光谱、紫外可见光谱和 HRMS 数据对化合物进行了表征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of Pyridinium Moiety Containing Triazolyl Purines
Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives in water. Target structures were obtained using the tosylation of hydroxyl groups of 2-(6-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2-(piperidin-1-yl)-9H-purin-9-yl)propane-1,3-diol, the subsequent introduction of pyridine, and ion exchange. The compounds were characterized using 1H- and 13C-NMR spectra, FTIR, UV–Vis, and HRMS data.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信