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引用次数: 0
摘要
实体器官移植后出现新的供体特异性 HLA 抗体(dnDSA)被认为是长期异体移植效果不佳的主要风险因素。预测 dnDSA 的发生是移植受者的福音,但对同种 HLA 免疫原性的评估仍不精确。尽管近来技术不断进步,但仍有必要全面评估异体 HLA 免疫原性,包括 B 细胞和 T 细胞的异体识别。最近的研究提出将不匹配的 HLA 表位(抗体和 T 细胞)作为体液同种异体免疫的预后生物标志物。然而,尽管在识别允许的错配方面取得了重大进展,但识别免疫原性 HLA 错配的工作仍未取得进展。当然,预测 dnDSA 的发展可能有利于允许的 HLA 错配器官移植、个性化免疫抑制和临床试验设计。然而,除了列出不匹配的 HLA 抗体表位和 T 细胞表位外,还需要其他特征,如 HLA T 细胞表位汇集的产生、受者的 HLA II 类表型和免疫抑制方案,以精确评估异体 HLA 免疫原性。
Allogeneic HLA Humoral Immunogenicity and the Prediction of Donor-Specific HLA Antibody Development
The development of de novo donor-specific HLA antibodies (dnDSAs) following solid organ transplantation is considered a major risk factor for poor long-term allograft outcomes. The prediction of dnDSA development is a boon to transplant recipients, yet the assessment of allo-HLA immunogenicity remains imprecise. Despite the recent technological advances, a comprehensive evaluation of allo-HLA immunogenicity, which includes both B and T cell allorecognition, is still warranted. Recent studies have proposed using mismatched HLA epitopes (antibody and T cell) as a prognostic biomarker for humoral alloimmunity. However, the identification of immunogenic HLA mismatches has not progressed despite significant improvements in the identification of permissible mismatches. Certainly, the prediction of dnDSA development may benefit permissible HLA mismatched organ transplantations, personalized immunosuppression, and clinical trial design. However, characteristics that go beyond the listing of mismatched HLA antibody epitopes and T cell epitopes, such as the generation of HLA T cell epitope repertoires, recipient’s HLA class II phenotype, and immunosuppressive regiments, are required for the precise assessment of allo-HLA immunogenicity.
期刊介绍:
Antibodies (ISSN 2073-4468), an international, peer-reviewed open access journal which provides an advanced forum for studies related to antibodies and antigens. It publishes reviews, research articles, communications and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided. Electronic files or software regarding the full details of the calculation and experimental procedure - if unable to be published in a normal way - can be deposited as supplementary material. This journal covers all topics related to antibodies and antigens, topics of interest include (but are not limited to): antibody-producing cells (including B cells), antibody structure and function, antibody-antigen interactions, Fc receptors, antibody manufacturing antibody engineering, antibody therapy, immunoassays, antibody diagnosis, tissue antigens, exogenous antigens, endogenous antigens, autoantigens, monoclonal antibodies, natural antibodies, humoral immune responses, immunoregulatory molecules.