心脏性猝死--病因、风险因素和人口统计学特征:对 1618 例法医尸检的广泛研究

Diseases Pub Date : 2024-07-25 DOI:10.3390/diseases12080168
Ioana Radu, Anca Otilia Farcas, Victoria Nyulas, Carmen Corina Radu, K. Brinzaniuc
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摘要

背景:心脏性猝死(SCD)是全球关注的一大公共卫生问题,影响着各个年龄段和社会群体。研究方法在这项回顾性研究中,在法医学研究所进行的 8265 例尸检中,纳入了 1618 例 SCD 病例。本研究旨在确定导致 SCD 的人口统计学特征、病因、流行病学特征和风险因素。研究结果SCD发病率最高的年龄组为40-69岁(65.0%),其中71.6%为男性。其中 32.1%(520 例)发生在急诊室。冠状动脉粥样硬化性疾病是最常见的猝死原因,据报告占 89.8%(1453 例),60%(870 例)的病例存在三冠状动脉病变。尸检中发现的 SCD 病因包括急性心肌梗死 13.9%(225 例)、扩张型心肌病 43.9%(710 例)、心脏肥大 579 例(36.07%)、心包炎 1.9%(30 例)、心肌炎 1.73%(28 例)和心肌脂肪 5%(81 例)。除心外膜脂肪和体重指数外,还有 17.9%(290 人)的人饮酒,这是一个潜在的诱因。结论:根据法医尸检和组织学研究结果,SCD 的发病机制涉及多种因素,其中一些因素可以通过早期实施预防措施来消除。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sudden Cardiac Death-Etiology, Risk Factors and Demographic Characteristics: An Extensive Study of 1618 Forensic Autopsies
Background: Sudden cardiac death (SCD) is a major public health concern worldwide, affecting all age and social groups. Methods: In this retrospective study, of the 8265 autopsies performed in the Institute of Legal Medicine, 1618 cases of SCD were included. The aim of this study is to identify demographic characteristics, etiological factors, epidemiological characteristics and risk factors that lead to SCD. Results: The highest incidence of SCD was in age group 40–69 years (65.0%), 71.6% of this age group being men. Of the total number, 32.1% (520) occurred in the emergency room. The most common cause of sudden death is represented by coronary atherosclerotic disease, reported in 89.8% (1453) of cases, tricoronary lesions being found in 60% (870) of cases. Etiological factors of SCD encountered during autopsies were acute myocardial infarction in 13.9% (225), dilated cardiomyopathy 43.9% (710), cardiac hypertrophy 579 (36.07%), pericarditis 1.9% (30), myocarditis 1.73% (28) and adipositas cordis 5% (81). Along with epicardial fat and BMI, alcohol consumption was recorded in 17.9% (290), this being a potential trigger. Conclusions: Based on forensic autopsy and histological findings, a wide variety of factors are involved in the etiopathogenesis of SCD, some of which can be eliminated through preventive measures implemented early.
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