V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra
{"title":"作为心脏疾病标志物的儿科患者 B 型钠尿肽水平的定点估测","authors":"V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra","doi":"10.18203/2349-3291.ijcp20242023","DOIUrl":null,"url":null,"abstract":"Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU.\nMethods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress.\nResults: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients.\nConclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.","PeriodicalId":13870,"journal":{"name":"International Journal of Contemporary Pediatrics","volume":"16 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Point of care estimation of B type natriuretic peptide levels in pediatric patients as a marker of cardiac disease\",\"authors\":\"V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra\",\"doi\":\"10.18203/2349-3291.ijcp20242023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU.\\nMethods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress.\\nResults: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients.\\nConclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.\",\"PeriodicalId\":13870,\"journal\":{\"name\":\"International Journal of Contemporary Pediatrics\",\"volume\":\"16 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Contemporary Pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18203/2349-3291.ijcp20242023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Contemporary Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18203/2349-3291.ijcp20242023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Point of care estimation of B type natriuretic peptide levels in pediatric patients as a marker of cardiac disease
Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU.
Methods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress.
Results: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients.
Conclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.