作为心脏疾病标志物的儿科患者 B 型钠尿肽水平的定点估测

V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra
{"title":"作为心脏疾病标志物的儿科患者 B 型钠尿肽水平的定点估测","authors":"V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra","doi":"10.18203/2349-3291.ijcp20242023","DOIUrl":null,"url":null,"abstract":"Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU.\nMethods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress.\nResults: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients.\nConclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.","PeriodicalId":13870,"journal":{"name":"International Journal of Contemporary Pediatrics","volume":"16 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Point of care estimation of B type natriuretic peptide levels in pediatric patients as a marker of cardiac disease\",\"authors\":\"V. Bhaskar, Sumaira Khalil, Mani Raj, Prerna Batra\",\"doi\":\"10.18203/2349-3291.ijcp20242023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU.\\nMethods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress.\\nResults: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients.\\nConclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.\",\"PeriodicalId\":13870,\"journal\":{\"name\":\"International Journal of Contemporary Pediatrics\",\"volume\":\"16 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Contemporary Pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18203/2349-3291.ijcp20242023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Contemporary Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18203/2349-3291.ijcp20242023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:儿童心脏病的早期识别具有挑战性,因为儿童的症状和体征往往有限。我们研究的主要目的是比较入住 PICU 的心脏病和非心脏病儿科患者的 BNP 水平:本研究对 45 名入住 PICU 的患者进行了前瞻性研究。使用 i-STAT POC 设备(雅培,新泽西州东温莎)测量 BNP。年龄在 1 个月至 12 岁之间的患者被分为三组:1) 心脏病组,包括出现心力衰竭特征的患者;2) 入住 PICU 并出现呼吸困难的非心脏病患者;3) 无呼吸困难的重症非心脏病患者(PELOD 评分大于 20 分):心脏病组的平均 BNP 水平为 2273 (±1302) pg/ml,明显高于呼吸系统组(9655±1223 pg/ml)和其他危重病组(102±168)。BNP的ROC曲线下面积为0.956,当数值为837 pg/ml时,BNP对正确识别心脏病患者CHF的敏感性为93.3,特异性为93%:我们得出结论:心脏病患者的 BNP 水平明显较高,护理点 BNP 估值可轻松区分心脏病患者和非心脏病患者。我们还发现,虽然呼吸系统疾病患者的 BNP 也会升高,但与心脏病患者相比,其水平并不高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Point of care estimation of B type natriuretic peptide levels in pediatric patients as a marker of cardiac disease
Background: Early recognition of heart disease in children can be challenging, because children often have a limited repertoire of presenting signs and symptoms. Primary purpose of our study was to compare the levels of BNP in cardiac and non-cardiac pediatric patients admitted in PICU. Methods: The study was conducted prospectively on 45 patients admitted in PICU. The i-STAT POC device (Abbott, East Windsor, NJ) was used for BNP measurement. Patients aging 1 month to 12 years, were enrolled in three cohorts: 1) Cardiac cohort, consisting of patients presenting with features of heart failure, 2) non-cardiac patients admitted in PICU with respiratory distress, 3) Critically sick, non-cardiac patients (PELOD score >20) without respiratory distress. Results: Mean BNP levels in cardiac cohort were 2273 (±1302) pg/ml, which were significantly higher than those observed in respiratory cohort (9655±1223 pg/ml) and other critical illness group (102±168). The area under the ROC curve for BNP was 0.956 and at a value of 837 pg/ml, BNP has a sensitivity of 93.3 and a specificity of 93% to correctly identify CHF in cardiac patients. Conclusions: We concluded that BNP levels are significantly higher in cardiac patients and point of care BNP estimation can easily distinguish between cardiac and non-cardiac patients. We also found that though BNP is raised in respiratory illness as well, levels are not very high as compared to cardiac patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信