针对新出现疾病的新疫苗:应对全球健康挑战的免疫战略创新

Aliu Olalekan Olatunji, Janet Aderonke Olaboye, Chukwudi Cosmos Maha, Tolulope Olagoke Kolawole, Samira Abdul
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引用次数: 0

摘要

新发传染病对全球健康构成重大挑战,因此有必要开发创新疫苗和免疫策略。本综述探讨了疫苗技术的进步及其应对 COVID-19、寨卡和埃博拉等疾病的潜力。传统的疫苗开发方法虽然有效,但往往需要很长时间,这可能会阻碍对疾病爆发的快速反应。最近的创新技术,包括 mRNA 疫苗、病毒载体疫苗和蛋白质亚单位疫苗,已经证明有能力加快开发速度并提高疗效。尤其是 mRNA 疫苗,通过实现快速设计和生产,为该领域带来了革命性的变化,它们在抗击 COVID-19 方面的成功就是证明。病毒载体疫苗利用改良病毒来递送抗原,在激发强大的免疫反应方面已显示出前景。蛋白亚单位疫苗利用特定抗原刺激免疫,是一种有针对性的方法,副作用可能较小。此外,佐剂技术和给药系统的进步也提高了疫苗的稳定性和免疫反应。基因组学和生物信息学工具的整合进一步简化了新型抗原的鉴定和有效疫苗的设计。全球合作和资助对于支持这些创新和确保公平获得疫苗至关重要,尤其是在中低收入国家。公共卫生战略必须优先考虑疫苗的接受和分发,解决疫苗犹豫不决和后勤方面的挑战。本报告强调了持续投资疫苗研发的重要性,突出了新兴免疫技术在保障全球健康、防止未来流行病和大流行病方面的变革潜力。通过利用这些创新技术,全球社会可以加强对新发传染病的防备和应对,最终减少其对公共卫生的影响。关键词 疫苗 疾病 疫苗接种 全球健康
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging vaccines for emerging diseases: Innovations in immunization strategies to address global health challenges
 Emerging infectious diseases pose significant global health challenges, necessitating the development of innovative vaccines and immunization strategies. This review explores the advancements in vaccine technology and their potential to address diseases such as COVID-19, Zika, and Ebola. Traditional vaccine development methods, while effective, often require extensive timeframes, which can hinder rapid response to outbreaks. Recent innovations, including mRNA vaccines, viral vector vaccines, and protein subunit vaccines, have demonstrated the ability to accelerate development and enhance efficacy. mRNA vaccines, in particular, have revolutionized the field by enabling rapid design and production, as evidenced by their success against COVID-19. Viral vector vaccines, utilizing modified viruses to deliver antigens, have shown promise in eliciting robust immune responses. Protein subunit vaccines, which use specific antigens to stimulate immunity, offer a targeted approach with potentially fewer side effects. Additionally, advances in adjuvant technology and delivery systems have improved vaccine stability and immune response. The integration of genomic and bioinformatics tools has further streamlined the identification of novel antigens and the design of effective vaccines. Global collaboration and funding are crucial in supporting these innovations and ensuring equitable access to vaccines, particularly in low- and middle-income countries. Public health strategies must prioritize vaccine acceptance and distribution, addressing vaccine hesitancy and logistical challenges. This review underscores the importance of continued investment in vaccine research and development, highlighting the transformative potential of emerging immunization technologies in safeguarding global health against future epidemics and pandemics. By leveraging these innovations, the global community can enhance preparedness and response to emerging infectious diseases, ultimately reducing their impact on public health. Keywords:  Vaccines, Diseases, Vaccination, Global Health.
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