用于无创健康监测的柔性纳米材料传感器

Maximilian B. Kopp
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摘要

根据美国疾病控制中心(CDC)的数据,糖尿病是导致美国人死亡的第八大原因,而约有五分之一的患者不知道自己已经患病。目前的检测方法比较粗糙,使用的是需要针头的原始刺穿方法,而且不适合连续跟踪,这严重阻碍了人们及早发现和管理糖尿病。因此,开发一种无创血糖监测技术至关重要。本研究的主要目标是通过开发无缝集成到可穿戴设备中的纳米材料传感器,解决现有葡萄糖监测技术的局限性。选择 GeSe 这种新型二维材料是因为它具有柔韧性和光学响应性。利用简便的直接转移方法开发出了柔性偏振传感器。这些传感器旨在通过测量与葡萄糖分子相互作用后的光偏振,对血糖水平进行准确的非侵入式监测。为确保可靠性,传感器使用已知浓度的葡萄糖溶液进行校准。还开发了一种机器学习算法来提高测量精度。与传统的血糖监测设备相比,对纳米材料传感器进行了严格的测试,通过对照研究评估了它们在不同物体上的有效性。这种方法不仅证明了纳米材料在改变健康监测方面的可行性,而且突出了它们在显著提高糖尿病患者血糖监测的准确性和便利性方面的潜力。将基于纳米材料的传感器集成到可穿戴设备中,是在提高医疗保健技术的效率和可及性方面迈出的值得注意的一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flexible nanomaterial sensors for non-invasive health monitoring
According to the Center for Disease Control (CDC), diabetes is the eighth leading cause of death in the United States, while about 1 in 5 patients are unaware that they have been affected. Current detection methods are crude, using rudimentary pricking methods that require needles and being unconventional for continuous tracking, this strongly discourages people from early detection and management. Therefore, developing a non-invasive glucose monitoring technique is of utmost importance. The primary objective of this research is to address the limitations of existing glucose monitoring techniques through the development of nanomaterial sensors seamlessly integrated into wearable devices. A novel two-dimensional material, GeSe, is chosen for its flexibility and optical responsivity. Flexible polarimetric sensors are developed using a facile direct-transfer method. These sensors aim to provide accurate and non-invasive monitoring of blood glucose levels through measuring the light polarization after interaction with glucose molecules. To ensure reliability, the sensors are calibrated using glucose solutions with known concentrations. A machine-learning algorithm is developed to improve measurement accuracy. Rigorous testing of the nanomaterial sensors is conducted in comparison to traditional blood glucose monitoring devices, employing controlled studies that evaluated their effectiveness across different objects. This approach not only establishes the viability of nanomaterials in transforming health monitoring but also highlights their potential to significantly improve the accuracy and convenience of blood glucose monitoring for individuals managing diabetes. The integration of nanomaterial-based sensors into wearable devices represents a noteworthy stride towards enhancing the efficiency and accessibility of healthcare technologies.
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