短跑间歇训练可提高脑源性神经营养因子对大脑健康的益处--一种可能的分子信号干预措施

Biology Pub Date : 2024-07-26 DOI:10.3390/biology13080562
Xueqiang Zhu, Wenjia Chen, A. Thirupathi
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引用次数: 0

摘要

体育锻炼会对我们的身体产生重大影响,影响我们的功能能力、结构建立和分子构成。这些变化的程度取决于所使用的具体运动方案。例如,中低强度的运动可以在短期内激活重要的分子靶标,如 BDNF 介导的信号传导,而高强度的运动则可以使这些信号传导分子长期保持活跃状态。因此,推荐特定的运动以获得 BDNF 诱导的益处具有挑战性。此外,运动诱导的分子信号转导靶点可能会产生积极和消极的影响,有些运动会削弱这些靶点,有些则会激活它们。例如,通过运动提高 BDNF 浓度对大脑健康有益,但也可能对双相情感障碍等疾病产生负面影响。因此,需要更深入地了解具体的运动介导机制方法。本综述将深入探讨短跑运动介导的 BDNF 激活如何有助于保持大脑健康,并探讨潜在的分子干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sprint Interval Training Improves Brain-Derived Neurotropic Factor-Induced Benefits in Brain Health—A Possible Molecular Signaling Intervention
Physical exercise can significantly impact our bodies, affecting our functional capacity, structure establishment, and molecular makeup. The magnitude of these changes depends on the specific exercise protocols used. For instance, low-to-moderate-intensity exercise can activate important molecular targets in the short term, such as BDNF-mediated signaling, while high-intensity exercise can maintain these signaling molecules in the active state for a longer term. This makes it challenging to recommend specific exercises for obtaining BDNF-induced benefits. Additionally, exercise-induced molecular signaling targets can have positive and negative effects, with some exercises blunting these targets and others activating them. For example, increasing BDNF concentration through exercise can be beneficial for brain health, but it may also have a negative impact on conditions such as bipolar disorder. Therefore, a deeper understanding of a specific exercise-mediated mechanistic approach is required. This review will delve into how the sprint exercise-mediated activation of BDNF could help maintain brain health and explore potential molecular interventions.
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