Lijuan Zhang, Jian Ma, Tianming Zhao, Meiyan Han, Dege Zheng, R. Jayawardena, A. Mapook, Yongzhong Lu
{"title":"淡水真菌 Tubeufia longihelicospora 菌株 GZCC 23-0405 的抗菌代谢物","authors":"Lijuan Zhang, Jian Ma, Tianming Zhao, Meiyan Han, Dege Zheng, R. Jayawardena, A. Mapook, Yongzhong Lu","doi":"10.12982/cmjs.2024.053","DOIUrl":null,"url":null,"abstract":"In this study, five metabolites were successfully isolated from the culture medium of Tubeufia longihelicospora strain GZCC 23-0405, comprising two dimeric naphtha-γ-pyrones (1–2), two dimeric coumarins (3–4), and one alkaloid (5). The elucidation of their chemical structures relied on a combination of NMR, MS, and optical rotation methods. Interestingly, these compounds represent the first instances of such metabolites being isolated from helicosporous hyphomycetes. Additionally, compounds (1) and (2) exhibited significant antimicrobial potential, with MIC and MBC values of 62.0 μg mL-1 and 248 μg mL-1, respectively, against Pseudomonas aeruginosa. This study provides a comprehensive account of the extraction, isolation, structural characterization, and antimicrobial properties of these compounds, shedding light on their potential significance in the field of natural product research.","PeriodicalId":9884,"journal":{"name":"Chiang Mai Journal of Science","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial Metabolites from the Freshwater Fungus Tubeufia longihelicospora Strain GZCC 23-0405\",\"authors\":\"Lijuan Zhang, Jian Ma, Tianming Zhao, Meiyan Han, Dege Zheng, R. Jayawardena, A. Mapook, Yongzhong Lu\",\"doi\":\"10.12982/cmjs.2024.053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, five metabolites were successfully isolated from the culture medium of Tubeufia longihelicospora strain GZCC 23-0405, comprising two dimeric naphtha-γ-pyrones (1–2), two dimeric coumarins (3–4), and one alkaloid (5). The elucidation of their chemical structures relied on a combination of NMR, MS, and optical rotation methods. Interestingly, these compounds represent the first instances of such metabolites being isolated from helicosporous hyphomycetes. Additionally, compounds (1) and (2) exhibited significant antimicrobial potential, with MIC and MBC values of 62.0 μg mL-1 and 248 μg mL-1, respectively, against Pseudomonas aeruginosa. This study provides a comprehensive account of the extraction, isolation, structural characterization, and antimicrobial properties of these compounds, shedding light on their potential significance in the field of natural product research.\",\"PeriodicalId\":9884,\"journal\":{\"name\":\"Chiang Mai Journal of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chiang Mai Journal of Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.12982/cmjs.2024.053\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chiang Mai Journal of Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.12982/cmjs.2024.053","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
本研究从 Tubeufia longihelicospora 菌株 GZCC 23-0405 的培养液中成功分离出五种代谢物,包括两种二聚石脑油-γ-吡喃酮(1-2)、两种二聚香豆素(3-4)和一种生物碱(5)。这些化合物的化学结构是通过核磁共振、质谱和旋光等方法综合阐明的。有趣的是,这些化合物是首次从单孢真菌中分离出的此类代谢物。此外,化合物(1)和(2)表现出显著的抗菌潜力,对铜绿假单胞菌的 MIC 和 MBC 值分别为 62.0 μg mL-1 和 248 μg mL-1。本研究全面介绍了这些化合物的提取、分离、结构表征和抗菌特性,揭示了它们在天然产物研究领域的潜在意义。
Antimicrobial Metabolites from the Freshwater Fungus Tubeufia longihelicospora Strain GZCC 23-0405
In this study, five metabolites were successfully isolated from the culture medium of Tubeufia longihelicospora strain GZCC 23-0405, comprising two dimeric naphtha-γ-pyrones (1–2), two dimeric coumarins (3–4), and one alkaloid (5). The elucidation of their chemical structures relied on a combination of NMR, MS, and optical rotation methods. Interestingly, these compounds represent the first instances of such metabolites being isolated from helicosporous hyphomycetes. Additionally, compounds (1) and (2) exhibited significant antimicrobial potential, with MIC and MBC values of 62.0 μg mL-1 and 248 μg mL-1, respectively, against Pseudomonas aeruginosa. This study provides a comprehensive account of the extraction, isolation, structural characterization, and antimicrobial properties of these compounds, shedding light on their potential significance in the field of natural product research.
期刊介绍:
The Chiang Mai Journal of Science is an international English language peer-reviewed journal which is published in open access electronic format 6 times a year in January, March, May, July, September and November by the Faculty of Science, Chiang Mai University. Manuscripts in most areas of science are welcomed except in areas such as agriculture, engineering and medical science which are outside the scope of the Journal. Currently, we focus on manuscripts in biology, chemistry, physics, materials science and environmental science. Papers in mathematics statistics and computer science are also included but should be of an applied nature rather than purely theoretical. Manuscripts describing experiments on humans or animals are required to provide proof that all experiments have been carried out according to the ethical regulations of the respective institutional and/or governmental authorities and this should be clearly stated in the manuscript itself. The Editor reserves the right to reject manuscripts that fail to do so.