Katie K. Lovell, Rushan I. Momin, Harneet Singh Sangha, Steven R. Feldman, Rita O. Pichardo
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引用次数: 0
摘要
他松最初是为纺织品染色而合成的,在 20 世纪 30 年代因其抗菌特性而获得认可,从而被皮肤科用于麻风病和疱疹性皮炎的治疗。尽管美国食品和药物管理局(FDA)批准了对这些病症的治疗,但他松的标示外用途也在不断扩大,使其成为治疗各种皮肤病的重要选择。本综述旨在重点介绍多松在 FDA 适应症和标签外适应症中的常见用途。本综述将对那些将他松视为一线疗法或辅助疗法的疾病进行综述,并包括相关资源中的重点内容。此外,还概述了他松的药代动力学、药效学、适应症、剂量和安全性。他泼松的多功能性和安全性使其成为皮肤科中一种经济有效的治疗选择,特别是对于那些难以获得专门药物治疗的患者。此外,还介绍了正在进行的临床试验,以探索达泼松在新型皮肤病治疗中的疗效。多年来,他泼松一直是各种皮肤病的重要辅助治疗药物,其使用证据也在不断增加。
Dapsone, initially synthesized for textile dyeing, gained recognition in the 1930s for its antibacterial properties, leading to its utilization in dermatology for leprosy and dermatitis herpetiformis. Despite US Food and Drug Administration (FDA) approval for these conditions, dapsone’s off-label uses have expanded, making it a valuable option in various dermatologic conditions. This review seeks to highlight the common uses of dapsone in its FDA indications and off-label indications. Diseases in which dapsone is considered first-line therapy or adjunctive therapy are reviewed, with highlights from the resources included. An overview of dapsone’s pharmacokinetics, pharmacodynamics, indications, dosages, and safety profile are also reviewed. Dapsone’s versatility and safety profile make it a cost-effective treatment option in dermatology, particularly for patients with limited access to specialized medications. Ongoing clinical trials are also described exploring dapsone’s efficacy in novel dermatologic uses. Dapsone has been a valuable adjunctive therapy across various dermatologic conditions for years and evidence for its use continues to expand.
期刊介绍:
The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.