Nancy L Garcia, Mariana Rodrigues-Motta, Helio S Migon, Eva Petkova, Thaddeus Tarpey, R Todd Ogden, Julio O Giordano, Martin M Perez
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引用次数: 0
摘要
我们考虑通过一个潜在的多项式变量进行无监督分类,该变量将标量响应归类到包含标量和函数协变量的混合物模型的 L 个分量之一。这一过程可视为一个分层模型,第一层根据参数分布的混合物对标量响应进行建模,第二层通过包含功能和标量协变量的广义线性模型对混合物概率进行建模。将函数协变量视为向量的传统方法不仅存在维度诅咒,因为函数协变量的测量间隔可能非常小,导致模型高度参数化,而且没有考虑到数据的性质。我们使用基扩展来降低维度,并使用贝叶斯方法来估计参数,同时提供潜在分类向量的预测。该方法由两个现有方法不易处理的数据实例激发。第一个例子涉及识别临床试验中的安慰剂应答者(正态混合模型),另一个例子涉及预测挤奶奶牛的疾病(泊松模型的零膨胀混合)。
Unsupervised Bayesian classification for models with scalar and functional covariates.
We consider unsupervised classification by means of a latent multinomial variable which categorizes a scalar response into one of the L components of a mixture model which incorporates scalar and functional covariates. This process can be thought as a hierarchical model with the first level modelling a scalar response according to a mixture of parametric distributions and the second level modelling the mixture probabilities by means of a generalized linear model with functional and scalar covariates. The traditional approach of treating functional covariates as vectors not only suffers from the curse of dimensionality, since functional covariates can be measured at very small intervals leading to a highly parametrized model, but also does not take into account the nature of the data. We use basis expansions to reduce the dimensionality and a Bayesian approach for estimating the parameters while providing predictions of the latent classification vector. The method is motivated by two data examples that are not easily handled by existing methods. The first example concerns identifying placebo responders on a clinical trial (normal mixture model) and the other predicting illness for milking cows (zero-inflated mixture of the Poisson model).
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.