丙酮酸脱氢酶复合物处于乙酰化和乳化的表观遗传学交叉路口。

IF 3.7 2区生物学 Q2 ENDOCRINOLOGY & METABOLISM

Molecular genetics and metabolism Pub Date : 2024-07-16 DOI:10.1016/j.ymgme.2024.108540

Peter W. Stacpoole , Carolyn O. Dirain

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引用次数: 0

摘要

丙酮酸脱氢酶复合物（PDC）因其大小和结构以及生理和病理上的重要性而引人注目。它的典型位置在线粒体基质中，通过将来自糖酵解的丙酮酸脱羧为乙酰-CoA，为三羧酸（TCA）循环提供能量。但人们对它在帮助塑造表观遗传景观方面的作用了解较少，从哺乳动物的早期发育到整个生命过程，它都能在细胞核中 "月光"，对人类的健康和寿命产生重大影响。PDC 对乙酰化和乳化这两种表观基因组关键修饰因子的影响是本篇简要综述的重点。

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The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation

The pyruvate dehydrogenase complex (PDC) is remarkable for its size and structure as well as for its physiological and pathological importance. Its canonical location is in the mitochondrial matrix, where it primes the tricarboxylic acid (TCA) cycle by decarboxylating glycolytically-derived pyruvate to acetyl-CoA. Less well appreciated is its role in helping to shape the epigenetic landscape, from early development throughout mammalian life by its ability to “moonlight” in the nucleus, with major repercussions for human healthspan and lifespan. The PDC's influence on two crucial modifiers of the epigenome, acetylation and lactylation, is the focus of this brief review.

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来源期刊

Molecular genetics and metabolism 生物-生化与分子生物学

CiteScore

5.90

自引率

7.90%

发文量

621

审稿时长

34 days

期刊介绍： Molecular Genetics and Metabolism contributes to the understanding of the metabolic and molecular basis of disease. This peer reviewed journal publishes articles describing investigations that use the tools of biochemical genetics and molecular genetics for studies of normal and disease states in humans and animal models.