{"title":"巴基斯坦单个中心儿童急性淋巴细胞白血病的临床特征和细胞遗传学。","authors":"Najia Tabassum, Sadia Muhammad, Talat Mirza, Zainab Butt, Neelum Mansoor","doi":"10.1177/2333794X241256863","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objectives.</i> This study aimed to find the association between clinical characteristics, cytogenetics, and post-induction outcomes of childhood acute lymphoblastic leukemia. <i>Methods.</i> The study was conducted at the Indus Hospital in Karachi. Initial total leukocyte count (TLC), cytogenetics, CNS status, and post-induction remission status were recorded. <i>Results.</i> Out of 108 children diagnosed with ALL, 66 (61.1%) were male and 42 (38.9%) were female. The majority 90 (83.3%) had B-ALL. CNS1 status was observed in 76 (84.4%) B-ALL and 18 (88.9%) T-ALL. All T-ALL and 89 (98.8%) B-ALL achieved remission post-induction. In B-ALL, 50 (55.5%) had a normal diploid karyotype, and 22 (24.4%) had numerical abnormalities. No typical gene rearrangement was observed in 66 (73.3%), 11 (12.2%) had BCR::ABL1, 10 (11.1%) had ETV6::RUNX1 and 3 (3.3%) KMT2A on FISH. No significant difference was observed between cytogenetics and clinical characteristics (<i>P</i> > .05). <i>Conclusion.</i> The study provides valuable data on childhood acute lymphoblastic leukemia in the Pakistani population.</p>","PeriodicalId":12576,"journal":{"name":"Global Pediatric Health","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283658/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical Characteristics and Cytogenetics of Childhood Acute Lymphoblastic Leukemia in a Single Center in Pakistan.\",\"authors\":\"Najia Tabassum, Sadia Muhammad, Talat Mirza, Zainab Butt, Neelum Mansoor\",\"doi\":\"10.1177/2333794X241256863\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objectives.</i> This study aimed to find the association between clinical characteristics, cytogenetics, and post-induction outcomes of childhood acute lymphoblastic leukemia. <i>Methods.</i> The study was conducted at the Indus Hospital in Karachi. Initial total leukocyte count (TLC), cytogenetics, CNS status, and post-induction remission status were recorded. <i>Results.</i> Out of 108 children diagnosed with ALL, 66 (61.1%) were male and 42 (38.9%) were female. The majority 90 (83.3%) had B-ALL. CNS1 status was observed in 76 (84.4%) B-ALL and 18 (88.9%) T-ALL. All T-ALL and 89 (98.8%) B-ALL achieved remission post-induction. In B-ALL, 50 (55.5%) had a normal diploid karyotype, and 22 (24.4%) had numerical abnormalities. No typical gene rearrangement was observed in 66 (73.3%), 11 (12.2%) had BCR::ABL1, 10 (11.1%) had ETV6::RUNX1 and 3 (3.3%) KMT2A on FISH. No significant difference was observed between cytogenetics and clinical characteristics (<i>P</i> > .05). <i>Conclusion.</i> The study provides valuable data on childhood acute lymphoblastic leukemia in the Pakistani population.</p>\",\"PeriodicalId\":12576,\"journal\":{\"name\":\"Global Pediatric Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283658/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Global Pediatric Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/2333794X241256863\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Pediatric Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2333794X241256863","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
研究目的本研究旨在发现儿童急性淋巴细胞白血病的临床特征、细胞遗传学和诱导后结果之间的关联。研究方法研究在卡拉奇的印度河医院进行。记录了初始白细胞总数（TLC）、细胞遗传学、中枢神经系统状况和诱导后缓解状况。结果。在确诊为 ALL 的 108 名儿童中，66 名（61.1%）为男性，42 名（38.9%）为女性。大多数 90 名（83.3%）患儿为 B 型 ALL。在76例（84.4%）B-ALL和18例（88.9%）T-ALL中观察到CNS1状态。所有 T-ALL 和 89 例（98.8%）B-ALL 在诱导后均获得缓解。在B-ALL中，50例（55.5%）的二倍体核型正常，22例（24.4%）有数字异常。66例（73.3%）未观察到典型的基因重排，11例（12.2%）有BCR::ABL1，10例（11.1%）有ETV6::RUNX1，3例（3.3%）有KMT2A。细胞遗传学与临床特征之间无明显差异（P > .05）。结论该研究提供了巴基斯坦儿童急性淋巴细胞白血病的宝贵数据。
Clinical Characteristics and Cytogenetics of Childhood Acute Lymphoblastic Leukemia in a Single Center in Pakistan.
Objectives. This study aimed to find the association between clinical characteristics, cytogenetics, and post-induction outcomes of childhood acute lymphoblastic leukemia. Methods. The study was conducted at the Indus Hospital in Karachi. Initial total leukocyte count (TLC), cytogenetics, CNS status, and post-induction remission status were recorded. Results. Out of 108 children diagnosed with ALL, 66 (61.1%) were male and 42 (38.9%) were female. The majority 90 (83.3%) had B-ALL. CNS1 status was observed in 76 (84.4%) B-ALL and 18 (88.9%) T-ALL. All T-ALL and 89 (98.8%) B-ALL achieved remission post-induction. In B-ALL, 50 (55.5%) had a normal diploid karyotype, and 22 (24.4%) had numerical abnormalities. No typical gene rearrangement was observed in 66 (73.3%), 11 (12.2%) had BCR::ABL1, 10 (11.1%) had ETV6::RUNX1 and 3 (3.3%) KMT2A on FISH. No significant difference was observed between cytogenetics and clinical characteristics (P > .05). Conclusion. The study provides valuable data on childhood acute lymphoblastic leukemia in the Pakistani population.
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