通过实施手术前工具包(OPTI-Surg)改善老年癌症患者的手术护理和疗效--III 期分组随机试验的最终结果(Alliance A231601CD)。

IF 7.5 1区 医学 Q1 SURGERY
Annals of surgery Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI:10.1097/SLA.0000000000006458
George J Chang, Heather J Gunn, Anne K Barber, Lisa M Lowenstein, Daniel Dohan, Jeanette Broering, Travis Dockter, Angelina D Tan, Amylou Dueck, Selina Chow, Heather Neuman, Emily Finlayson
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引用次数: 0

摘要

目的评估实践层面的术前虚弱筛查和优化工具包(OPTI-Surg)对接受大手术的老年癌症患者术后功能恢复和并发症的影响:虚弱在老年人中很常见,它会增加术后功能恢复不良和并发症的风险。实践层面的筛查/优化干预对改善预后的潜力尚不清楚:方法:在NCI社区肿瘤学研究项目(NCORP)中,胸腔、胃肠道和泌尿系统肿瘤外科医生按1:1:1的比例被随机分配到常规护理(UC)、OPTI-Surg或带实施指导的OPTI-Surg中。OPTI-Surg 包括埃德蒙顿虚弱量表和转诊干预指导建议。年龄≥70岁接受根治性手术的患者均符合条件。主要结果是术后 8 周的功能(千卡/周)。主要次要结果是 90 天内的并发症。混合模型用于比较UC与2个OPTI-Surg臂的组合:结果:从2019年7月至2022年9月,29家医疗机构共招募了325名患者。分别有 199 例(64 例 UC,135 例 OPTI-Surg)和 279 例(78 例 UC,201 例 OPTI-Surg)可进行主要和次要分析评估。在对基线功能进行调整后(P=0.53),尿毒症患者和 OPTI-Surg 患者在总热量消耗上没有明显差异(尿毒症患者 2.2,OPTI-Surg 患者 2.0)。UC和OPTI-Surg患者在术后并发症方面没有明显差异(UC为25.6%,OPTI-Surg为35.3%,P=0.5):结论:虚弱评估已成功实施,但与 UC 相比,OPTI-Surg 干预既没有改善术后功能,也没有减少术后并发症。未来的分析将探讨与工具包实施相关的实践层面因素,以及指导臂和非指导臂之间的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving Surgical Care and Outcomes in Older Cancer Patients Through Implementation of a Presurgical Toolkit (OPTI-Surg)-Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD).

Objective: To assess the effect of a practice-level preoperative frailty screening and optimization toolkit (OPTI-Surg) on postoperative functional recovery and complications in elderly cancer patients undergoing major surgery.

Background: Frailty is common in older adults. It increases the risk of poor postoperative functional recovery and complications. The potential for a practice-level screening/optimization intervention to improve outcomes is unknown.

Methods: Thoracic, gastrointestinal, and urologic oncological surgery practices within the National Cancer Institute Community Oncology Research Program (NCORP) were randomized 1:1:1 to usual care (UC), OPTI-Surg, or OPTI-Surg with an implementation coach. OPTI-Surg consisted of the Edmonton Frail Scale and guided recommendations for referral interventions. Patients 70 years old or above undergoing curative intent surgery were eligible. The primary outcome was 8 weeks postoperative function (kcal/wk). The key secondary outcome was complications within 90 days. Mixed models were used to compare UC to the 2 OPTI-Surg arms combined.

Results: From July 2019 to September 2022, 325 patients were enrolled in 29 practices. One hundred ninety-nine (64 UC, 135 OPTI-Surg) and 279 (78 UC, 201 OPTI-Surg) were evaluable for primary and secondary analysis, respectively. UC and OPTI-Surg patients did not significantly differ in total caloric expenditure (2.2 UC, 2.0 OPTI-Surg) after adjusting for baseline function ( P =0.53). UC and OPTI-Surg patients did not significantly differ in postoperative complications (25.6% UC, 35.3% OPTI-Surg, P =0.5).

Conclusions: Frailty assessment was successfully performed, but the OPTI-Surg intervention did not improve postoperative function nor reduce postoperative complications compared with UC. Future analysis will explore practice-level factors associated with toolkit implementation and the differences between the coaching and noncoaching arms.

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来源期刊
Annals of surgery
Annals of surgery 医学-外科
CiteScore
14.40
自引率
4.40%
发文量
687
审稿时长
4 months
期刊介绍: The Annals of Surgery is a renowned surgery journal, recognized globally for its extensive scholarly references. It serves as a valuable resource for the international medical community by disseminating knowledge regarding important developments in surgical science and practice. Surgeons regularly turn to the Annals of Surgery to stay updated on innovative practices and techniques. The journal also offers special editorial features such as "Advances in Surgical Technique," offering timely coverage of ongoing clinical issues. Additionally, the journal publishes monthly review articles that address the latest concerns in surgical practice.
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