对 Chen 和 Heitjan 的 "不完全依从性临床试验中估计值的敏感性 "的评论

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-27 DOI:10.1515/ijb-2023-0127

Stuart G. Baker, Karen S. Lindeman

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引用次数: 0

摘要

Chen and Heitjan (Sensitivity of estimands in clinical trials with imperfect compliance.Int J Biostat.2023）使用线性外推法，在全遵从或无遵从的多项随机试验中，从遵从者平均因果效应（CACE）估算出人群平均因果效应（PACE）。在这种情况下，以及在涉及前后研究中不同治疗可用性的配对可用性设计中，要从 CACE 外推到 PACE，我们推荐使用 Baker 和 Lindeman（《因果推论》，2013 年）中的敏感性分析，因为它不局限于线性模型，还涉及各种随机效应和趋势模型。

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Comments on “sensitivity of estimands in clinical trials with imperfect compliance” by Chen and Heitjan

Chen and Heitjan (Sensitivity of estimands in clinical trials with imperfect compliance. Int J Biostat. 2023) used linear extrapolation to estimate the population average causal effect (PACE) from the complier average causal effect (CACE) in multiple randomized trials with all-or-none compliance. For extrapolating from CACE to PACE in this setting and in the paired availability design involving different availabilities of treatment among before-and-after studies, we recommend the sensitivity analysis in Baker and Lindeman (J Causal Inference, 2013) because it is not restricted to a linear model, as it involves various random effect and trend models.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.