儿童期口吃患者血浆中的硫胺素和组胺水平

IF 0.7 4区医学 Q4 REHABILITATION

Communication Disorders Quarterly Pub Date : 2024-07-25 DOI:10.1177/15257401241263321

Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid

{"title":"儿童期口吃患者血浆中的硫胺素和组胺水平","authors":"Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid","doi":"10.1177/15257401241263321","DOIUrl":null,"url":null,"abstract":"This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.","PeriodicalId":46403,"journal":{"name":"Communication Disorders Quarterly","volume":"41 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasma Levels of Thiamine and Histamine in Childhood-Onset Stuttering\",\"authors\":\"Mazin T. Alqhazo, Dianne F. Newbury, Ayat B. Rashaid\",\"doi\":\"10.1177/15257401241263321\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.\",\"PeriodicalId\":46403,\"journal\":{\"name\":\"Communication Disorders Quarterly\",\"volume\":\"41 1\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Communication Disorders Quarterly\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15257401241263321\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"REHABILITATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communication Disorders Quarterly","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15257401241263321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"REHABILITATION","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在比较41名说话流利的正常人和43名口吃儿童样本中硫胺素和组胺的浓度。研究人员采集了血液样本，使用高效液相色谱-紫外检测器（HPLC-UV）测定硫胺素和组胺。结果显示，与对照组相比，口吃组的硫胺素水平明显偏低（M = 29.9，SD = 15.6）（M = 38，SD = 19.3，p = .02）；与对照组相比，口吃组的组胺水平明显偏高（M = 20.5，SD = 6.5）（M = 9.4，SD = 7.5，p ≤ .00）。结果还表明，严重程度评分与组胺水平之间存在明显的负相关。本研究的结果可为儿童口吃与硫胺素和组胺等生物标志物之间的关系提供进一步的佐证信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Plasma Levels of Thiamine and Histamine in Childhood-Onset Stuttering

This study aims to compare the concentrations of thiamine and histamine in the samples of 41 normal fluent speakers and 43 children who stutter. Blood samples were collected for the determination of thiamine and histamine using high-performance liquid chromatography coupled to ultraviolet detector (HPLC-UV). The results revealed a significantly lower level of thiamine in the stuttering group ( M = 29.9, SD = 15.6) compared with the control group ( M = 38, SD = 19.3, p = .02), and a significantly higher level of histamine in the stuttering group ( M = 20.5, SD = 6.5) compared with the control group ( M = 9.4, SD = 7.5, p ≤ .00). The results also indicated a significant negative correlation between severity scores and the level of histamine. The findings of the current study may provide further supporting information about the relationship between childhood-onset stuttering and some biological markers such as thiamine and histamine.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Communication Disorders Quarterly REHABILITATION-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Articles for Communication Disorders Quarterly (CDQ) are accepted for review on a continual basis. The editor of CDQ welcomes submissions of previously unpublished applied and clinical research relating to typical and atypical communication across the lifespan. This includes assessment of and interventions for communicative disorders in infants, toddlers, young children, school-age children, youth, and adults. The readers of CDQ represent a breadth of viewpoints and professional interests, which is also reflected in the diversity of interests and expertise of the editorial board members. The journal is particularly of interest to speech–language pathologists and teachers of the deaf and hard of hearing. CDQ uses a masked peer review process for submissions.