脂质双分子层的层间耦合强度可控制脂质结构域的大小

IF 0.8 4区 物理与天体物理 Q3 PHYSICS, MULTIDISCIPLINARY
Kan Sornbundit
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引用次数: 0

摘要

本文利用耗散粒子动力学(DPD)模拟研究了脂质双分子层对立层间相互作用强度的影响。浸入水中的脂质双分子层由代表饱和脂质和不饱和脂质的两种脂质组成。这项研究的重点是脂质双分子层接近临界温度的情况。在这种情况下,处于这种状态的脂质结构域体积小、不稳定、寿命短。这些脂质域的行为类似于等离子体膜中的脂质筏概念。据推测,脂质筏的每种功能都需要不同的时间尺度。最新研究还表明,脂质筏的寿命取决于其大小。我们的研究结果表明,筏状脂质域的大小和存在取决于层间耦合的强度。与较弱的耦合相比,较强的耦合强度倾向于稳定脂质域,从而使其尺寸更大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Inter-layer coupling strength in lipid bilayer can control the size of lipid domains

Inter-layer coupling strength in lipid bilayer can control the size of lipid domains

Inter-layer coupling strength in lipid bilayer can control the size of lipid domains

In this article, we investigate the effect of the inter-layer interaction strength across the opposed layers of a lipid bilayer using dissipative particle dynamics (DPD) simulations. The lipid bilayer, immersed in water, was composed of two types of lipids representing saturated and unsaturated lipids. This research focuses on the situations where the lipid bilayer nears its critical temperature. In this situation, lipid domains in this regime are small, unstable, and have short lifespans. The behavior of these lipid domains resembles the concept of lipid rafts in plasma membranes. It is postulated that each function of lipid rafts requires a different time scale. Recent research also shows that the lifetime of a lipid raft depends on its size. Our findings indicate that the size and existence of raft-like lipid domains depend on the strength of the coupling between layers. Strong coupling strengths tend to stabilize the lipid domain, resulting in larger sizes compared to weaker coupling.

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来源期刊
Journal of the Korean Physical Society
Journal of the Korean Physical Society PHYSICS, MULTIDISCIPLINARY-
CiteScore
1.20
自引率
16.70%
发文量
276
审稿时长
5.5 months
期刊介绍: The Journal of the Korean Physical Society (JKPS) covers all fields of physics spanning from statistical physics and condensed matter physics to particle physics. The manuscript to be published in JKPS is required to hold the originality, significance, and recent completeness. The journal is composed of Full paper, Letters, and Brief sections. In addition, featured articles with outstanding results are selected by the Editorial board and introduced in the online version. For emphasis on aspect of international journal, several world-distinguished researchers join the Editorial board. High quality of papers may be express-published when it is recommended or requested.
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