{"title":"脂质双分子层的层间耦合强度可控制脂质结构域的大小","authors":"Kan Sornbundit","doi":"10.1007/s40042-024-01144-1","DOIUrl":null,"url":null,"abstract":"<div><p>In this article, we investigate the effect of the inter-layer interaction strength across the opposed layers of a lipid bilayer using dissipative particle dynamics (DPD) simulations. The lipid bilayer, immersed in water, was composed of two types of lipids representing saturated and unsaturated lipids. This research focuses on the situations where the lipid bilayer nears its critical temperature. In this situation, lipid domains in this regime are small, unstable, and have short lifespans. The behavior of these lipid domains resembles the concept of lipid rafts in plasma membranes. It is postulated that each function of lipid rafts requires a different time scale. Recent research also shows that the lifetime of a lipid raft depends on its size. Our findings indicate that the size and existence of raft-like lipid domains depend on the strength of the coupling between layers. Strong coupling strengths tend to stabilize the lipid domain, resulting in larger sizes compared to weaker coupling.</p></div>","PeriodicalId":677,"journal":{"name":"Journal of the Korean Physical Society","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inter-layer coupling strength in lipid bilayer can control the size of lipid domains\",\"authors\":\"Kan Sornbundit\",\"doi\":\"10.1007/s40042-024-01144-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this article, we investigate the effect of the inter-layer interaction strength across the opposed layers of a lipid bilayer using dissipative particle dynamics (DPD) simulations. The lipid bilayer, immersed in water, was composed of two types of lipids representing saturated and unsaturated lipids. This research focuses on the situations where the lipid bilayer nears its critical temperature. In this situation, lipid domains in this regime are small, unstable, and have short lifespans. The behavior of these lipid domains resembles the concept of lipid rafts in plasma membranes. It is postulated that each function of lipid rafts requires a different time scale. Recent research also shows that the lifetime of a lipid raft depends on its size. Our findings indicate that the size and existence of raft-like lipid domains depend on the strength of the coupling between layers. Strong coupling strengths tend to stabilize the lipid domain, resulting in larger sizes compared to weaker coupling.</p></div>\",\"PeriodicalId\":677,\"journal\":{\"name\":\"Journal of the Korean Physical Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Korean Physical Society\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40042-024-01144-1\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Korean Physical Society","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s40042-024-01144-1","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Inter-layer coupling strength in lipid bilayer can control the size of lipid domains
In this article, we investigate the effect of the inter-layer interaction strength across the opposed layers of a lipid bilayer using dissipative particle dynamics (DPD) simulations. The lipid bilayer, immersed in water, was composed of two types of lipids representing saturated and unsaturated lipids. This research focuses on the situations where the lipid bilayer nears its critical temperature. In this situation, lipid domains in this regime are small, unstable, and have short lifespans. The behavior of these lipid domains resembles the concept of lipid rafts in plasma membranes. It is postulated that each function of lipid rafts requires a different time scale. Recent research also shows that the lifetime of a lipid raft depends on its size. Our findings indicate that the size and existence of raft-like lipid domains depend on the strength of the coupling between layers. Strong coupling strengths tend to stabilize the lipid domain, resulting in larger sizes compared to weaker coupling.
期刊介绍:
The Journal of the Korean Physical Society (JKPS) covers all fields of physics spanning from statistical physics and condensed matter physics to particle physics. The manuscript to be published in JKPS is required to hold the originality, significance, and recent completeness. The journal is composed of Full paper, Letters, and Brief sections. In addition, featured articles with outstanding results are selected by the Editorial board and introduced in the online version. For emphasis on aspect of international journal, several world-distinguished researchers join the Editorial board. High quality of papers may be express-published when it is recommended or requested.