Molecular Imprinting-Involving Highly Selective Tetracycline Detection Platform Based on Mn2V2O7 with Excellent Oxidase-Mimicking Activity

Nanozymes-involving colorimetry may represent an effective solution to tetracycline detection due to its affordability and simplicity. To improve the performance in selectivity, molecular imprinting technology has emerged as a promising approach to simulating the interaction between antibodies and receptors. Herein, Mn₂V₂O₇, a form of nanozyme with oxidase-mimicking activity, was synthesized. With tetracycline as the template, the cavities with unique dimensions were constructed through the self-polymerization of dopamine (DA) on Mn₂V₂O₇. In Mn₂V₂O₇@MIP, polydopamine (PDA) acts as molecularly imprinted polymer (MIP) and its cavities are compatible with tetracycline in dimension. It also exhibits oxidase-mimicking activity. With the introduction of tetracycline, the cavity of PDA is blocked, which leads to obvious color fading, which enables precise tetracycline detection with colorimetry. The range of linear detection is from 10 to 100 μM, and the lower limit of detection is 0.82 μM. It is anticipated that the combination between nanozymes-involving colorimetry and molecular imprinting technology would contribute to the accurate detection of organic pollutants in the aquatic environment.