连接肌动蛋白流动和粘附动力学的一维细胞迁移活性凝胶模型

IF 2.8 2区 物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY
Valentin Wössner, Oliver M Drozdowski, Falko Ziebert and Ulrich S Schwarz
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引用次数: 0

摘要

动物细胞的迁移基于前端的肌动蛋白聚合、沿细胞-基质界面的粘附和后端的肌动蛋白收缩之间的相互作用。活性凝胶理论曾被用于证明肌动蛋白收缩力足以在没有外部线索的情况下实现极化和自我维持的细胞迁移,但并未考虑粘附的动态变化。同样,基于粘附受体机械敏感动力学的迁移模型通常也不包括细胞内流动的整体动力学。在此,我们展示了一个最小活性凝胶模型,该模型可将这两方面结合起来,用于具有动态粘附的一维细胞迁移。该模型表明,粘附受体之间的负载分担会导致对称性打破,前端的粘附力更强,而迁移的双稳态性产生于中间粘附力。粘附力的局部变化足以在无柄状态和运动状态之间切换,这与实验结果基本一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics
Migration of animal cells is based on the interplay between actin polymerization at the front, adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active gel theory has been used before to demonstrate that actomyosin contractility is sufficient for polarization and self-sustained cell migration in the absence of external cues, but did not consider the dynamics of adhesion. Likewise, migration models based on the mechanosensitive dynamics of adhesion receptors usually do not include the global dynamics of intracellular flow. Here we show that both aspects can be combined in a minimal active gel model for one-dimensional cell migration with dynamic adhesion. This model demonstrates that load sharing between the adhesion receptors leads to symmetry breaking, with stronger adhesion at the front, and that bistability of migration arises for intermediate adhesiveness. Local variations in adhesiveness are sufficient to switch between sessile and motile states, in qualitative agreement with experiments.
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来源期刊
New Journal of Physics
New Journal of Physics 物理-物理:综合
CiteScore
6.20
自引率
3.00%
发文量
504
审稿时长
3.1 months
期刊介绍: New Journal of Physics publishes across the whole of physics, encompassing pure, applied, theoretical and experimental research, as well as interdisciplinary topics where physics forms the central theme. All content is permanently free to read and the journal is funded by an article publication charge.
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