葡萄糖依赖性促胰岛素多肽 (GIP) 在 T2DM 中的治疗潜力:过去、现在和未来。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Soumik Das, Harini Ravi, Achsha Babu, Manosi Banerjee, R Kanagavalli, Sivaraman Dhanasekaran, V Devi Rajeswari, Ganesh Venkatraman, Gnanasambandan Ramanathan
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引用次数: 0

摘要

2 型糖尿病(T2DM)是一个世界性的健康问题,引起了公共卫生界的极大关注。这种慢性病通常是由于细胞无法对正常的胰岛素水平做出反应所致。葡萄糖依赖性促胰岛素多肽(GIP)和胰高血糖素样肽-1(GLP-1)是肠道分泌的主要增量激素。尽管临床研究已广泛探索了 GLP-1R 在治疗各种 T2DM 相关异常方面的治疗潜力,但 GIPR 在 T2DM 治疗中发挥重要作用的可能性仍在研究之中。有证据表明,GIP 参与了 T2DM 的病理生理学。本章重点探讨 GIP 作为一种治疗分子在抗击 T2DM 中的作用,并对过去、现在和未来的情况进行比较。我们的目标是深入研究 GIP 如何影响胰岛β细胞功能、脂肪组织吸收和脂质代谢。此外,我们还将阐明 GIP 及其受体与其他临床疾病(如心血管疾病、非酒精性脂肪肝、神经退行性疾病和肾脏疾病)相关的机理功能。此外,本章还将阐明 T2DM 药物治疗的最新进展,重点介绍 GIP 的潜在结构修饰和药物的再利用,同时探讨将基于 GIP 的治疗方法引入临床实践所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potentials of glucose-dependent insulinotropic polypeptide (GIP) in T2DM: Past, present, and future.

Type 2 diabetes mellitus (T2DM) is a worldwide health problem that has raised major concerns to the public health community. This chronic condition typically results from the cell's inability to respond to normal insulin levels. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the primary incretin hormones secreted from the intestinal tract. While clinical research has extensively explored the therapeutic potential of GLP-1R in addressing various T2DM-related abnormalities, the possibility of GIPR playing an important role in T2DM treatment is still under investigation. Evidence suggests that GIP is involved in the pathophysiology of T2DM. This chapter focuses on examining the role of GIP as a therapeutic molecule in combating T2DM, comparing the past, present, and future scenarios. Our goal is to delve into how GIP may impact pancreatic β-cell function, adipose tissue uptake, and lipid metabolism. Furthermore, we will elucidate the mechanistic functions of GIP and its receptors in relation to other clinical conditions like cardiovascular diseases, non-alcoholic fatty liver diseases, neurodegenerative diseases, and renal disorders. Additionally, this chapter will shed light on the latest advancements in pharmacological management for T2DM, highlighting potential structural modifications of GIP and the repurposing of drugs, while also addressing the challenges involved in bringing GIP-based treatments into clinical practice.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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