心力衰竭患者肌动蛋白的诊断和预测能力。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Oleksandr O Berezin, Tetiana A Berezina, Uta C Hoppe, Michael Lichtenauer, Alexander E Berezin
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引用次数: 0

摘要

肌动素被定义为由骨骼肌细胞和心肌细胞表达、合成、产生和释放的多种细胞因子、多肽和代谢衍生物组成的异源群体,可发挥自分泌、旁分泌或内分泌作用。以往的研究表明,肌动素在骨骼肌、心肌和远处器官(如大脑、血管、骨骼、肝脏、胰腺、白脂肪组织、肠道和皮肤)之间的相互沟通中发挥着关键作用。尽管几种肌动因主要在调节骨骼肌肥大、居民细胞分化、新生血管/血管生成、血管完整性、内皮功能、炎症和凋亡/坏死、减轻缺血/缺氧和组织保护、肿瘤生长和恶性肿瘤等方面发挥着完全不同的生物学效应,但在其他场合,它们的主要效应影响着能量平衡、葡萄糖和脂质代谢、脂肪、肌肉训练适应性和饮食行为。近十年来,又有 250 种肌动蛋白被发现,多年来,人们一直在研究它们作为生物标志物或心衰治疗靶点的作用。然而,只有少数肌动蛋白被用作监测不良心脏重塑、缺血/缺氧相关靶器官功能障碍、微血管炎症、肌肉疏松症/肌病以及预测心力衰竭患者不良临床预后的有效工具。我们将集中讨论一些最可信的肌动因子,如肌生长因子、肌连蛋白、脑源性神经营养因子、肌肉蛋白、成纤维细胞生长因子 21、鸢尾素、白血病抑制因子、发育内皮位点-1、白细胞介素-6、神经生长因子和胰岛素样生长因子-1,它们被认为是心房颤动发生和发展的有用生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic and predictive abilities of myokines in patients with heart failure.

Myokines are defined as a heterogenic group of numerous cytokines, peptides and metabolic derivates, which are expressed, synthesized, produced, and released by skeletal myocytes and myocardial cells and exert either auto- and paracrine, or endocrine effects. Previous studies revealed that myokines play a pivotal role in mutual communications between skeletal muscles, myocardium and remote organs, such as brain, vasculature, bone, liver, pancreas, white adipose tissue, gut, and skin. Despite several myokines exert complete divorced biological effects mainly in regulation of skeletal muscle hypertrophy, residential cells differentiation, neovascularization/angiogenesis, vascular integrity, endothelial function, inflammation and apoptosis/necrosis, attenuating ischemia/hypoxia and tissue protection, tumor growth and malignance, for other occasions, their predominant effects affect energy homeostasis, glucose and lipid metabolism, adiposity, muscle training adaptation and food behavior. Last decade had been identified 250 more myokines, which have been investigating for many years further as either biomarkers or targets for heart failure management. However, only few myokines have been allocated to a promising tool for monitoring adverse cardiac remodeling, ischemia/hypoxia-related target-organ dysfunction, microvascular inflammation, sarcopenia/myopathy and prediction for poor clinical outcomes among patients with HF. This we concentrate on some most plausible myokines, such as myostatin, myonectin, brain-derived neurotrophic factor, muslin, fibroblast growth factor 21, irisin, leukemia inhibitory factor, developmental endothelial locus-1, interleukin-6, nerve growth factor and insulin-like growth factor-1, which are suggested to be useful biomarkers for HF development and progression.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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