精准肿瘤学中患者化身的兴起

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Lukas Ehlen, Michael Schmueck-Henneresse
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引用次数: 0

摘要

对抗癌治疗的反应不仅取决于肿瘤内分子靶点的可用性,还取决于肿瘤内高度异质性、患者特异性的细胞组成及其复杂的肿瘤微环境(TME)。因此,一些患者对抗癌疗法表现出显著的反应,而另一些患者的疗效则微乎其微。因此,亟需更有效的策略来预选患者接受治疗,从而降低使用无效和潜在有害药物的风险,加快患者接受最有效治疗的进程。根据患者化身对抗癌药物的反应为癌症患者量身定制治疗方案,可以改变治疗实体瘤患者的整个方法。尽管将这些人类体外系统引入临床环境一直具有挑战性,但最近的证据表明,这些模型已经做好了临床转化的准备。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The rise of patient avatars in precision oncology
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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