Saeedeh Salimi, Abbas Mohammadpour-Gharehbagh, Mohaddeseh Hedayat, Hamidreza Galavi, Mahdiyeh Harati-Sadegh
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引用次数: 0
摘要
目的：作者设计了一项荟萃分析，以全面了解 RNLS 多态性对子痫前期（PE）易感性的影响。研究方法采用在线数据库 PubMed、Scopus 和 Google Scholar 进行文献检索。使用 STATA（12.0 版）和 MetaGenyo 网络工具进行数据分析。结果研究结果表明，RNLS rs10887800 多态性在等位基因、共显性杂合子和显性遗传模型中可增加 PE 的风险。此外，分析表明，RNLS rs2576178 多态性在等位基因、显性同卵、显性和隐性遗传模型中与 PE 的高风险相关。结论荟萃分析结果表明，RNLS rs10887800 和 rs2576178 多态性可在多种遗传模型中增加 PE 风险。
The effect of RNLS gene polymorphisms on preeclampsia susceptibility: a meta-analysis study.
Aim: The authors designed a meta-analysis to find a comprehensive result of the impact of RNLS polymorphisms on preeclampsia (PE) susceptibility. Methods: The online databases PubMed, Scopus, and Google Scholar were employed for the purpose of literature search. Data analysis was conducted using STATA (ver. 12.0) and MetaGenyo web tool. Results: The findings showed that the RNLS rs10887800 polymorphism could increase risk of PE in allelic, codominant heterozygous and dominant genetic models. In addition, the analysis indicated that the RNLS rs2576178 polymorphism was associated with higher risk of PE in allelic, codominant homozygous, dominant, and recessive models. Conclusion: The findings of meta-analysis showed that the RNLS rs10887800 and rs2576178 polymorphisms could increase risk of PE in several genetic models.
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