哺乳动物心肌细胞发育的表观遗传调控

IF 2.5 Q3 GENETICS & HEREDITY
Isaiah K Mensah, Humaira Gowher
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引用次数: 0

摘要

心脏是哺乳动物发育过程中形成的第一个器官,其功能是向发育中胚胎的其他部位分配营养和氧气。心肌细胞是心脏的主要细胞类型,为心脏提供结构支持和收缩功能。在早期发育过程中,心肌细胞的成功分化受到物理和分子因素的严格调控。我们回顾了目前对心肌细胞分化至关重要的表观遗传因素的研究,包括 DNA 甲基化、组蛋白修饰、染色质重塑和非编码 RNA。本综述还全面详述了与胎儿和出生后心肌细胞分化相关的结构和形态学变化,并强调了它们之间的差异。全面了解心肌细胞发育的各个方面对于成功体外分化心肌细胞以达到治疗目的至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic Regulation of Mammalian Cardiomyocyte Development.

The heart is the first organ formed during mammalian development and functions to distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are the major cell types of the heart and provide both structural support and contractile function to the heart. The successful differentiation of cardiomyocytes during early development is under tight regulation by physical and molecular factors. We have reviewed current studies on epigenetic factors critical for cardiomyocyte differentiation, including DNA methylation, histone modifications, chromatin remodelers, and noncoding RNAs. This review also provides comprehensive details on structural and morphological changes associated with the differentiation of fetal and postnatal cardiomyocytes and highlights their differences. A holistic understanding of all aspects of cardiomyocyte development is critical for the successful in vitro differentiation of cardiomyocytes for therapeutic purposes.

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来源期刊
Epigenomes
Epigenomes GENETICS & HEREDITY-
CiteScore
3.80
自引率
0.00%
发文量
38
审稿时长
11 weeks
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