线粒体复合体在小胶质细胞中的复杂作用

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-07-24 DOI:10.1038/s42255-024-01095-8

Rosa C. Paolicelli, Stefano Pluchino

引用次数: 0

摘要

新陈代谢会影响各种细胞类型，小胶质细胞也不例外。最近发表在《自然-新陈代谢》（Nature Metabolism）上的两项研究表明，线粒体呼吸链因复合体 I 或复合体 III 的缺陷而受损，会以高度依赖环境的方式影响小胶质细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Complex roles for mitochondrial complexes in microglia

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Complex roles for mitochondrial complexes in microglia

Metabolism impacts various cellular types, and microglia are no exception. Two recent studies in Nature Metabolism demonstrate that impairing the mitochondrial respiratory chain, via deficiencies in complex I or complex III, affects microglia in a highly context-dependent manner.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.