最后，又是 POT1：磷酸化使人类端粒蛋白 POT1 能够招募富 C 链末端复制机器

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-07-25 DOI:10.1016/j.molcel.2024.06.030

引用次数: 0

摘要

最近，蔡（Cai）等人1在《细胞》（Cell）杂志上报道了人类保护蛋白POT1的磷酸化如何使其招募端粒富C链复制机制，为端粒生物学中一个未被充分研究的领域提供了机理上的见解，并对端粒生物学疾病产生了影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery

Recently in Cell, Cai et al.¹ reported how phosphorylation of human shelterin protein POT1 allows it to recruit the telomeric C-rich strand replication machinery, providing mechanistic insights into an understudied area of telomere biology with implications for telomere biology disorders.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.