细胞外小泡在皮肤中的作用及其与纳米颗粒的相互作用。

World journal of nanoscience and nanotechnology Pub Date : 2020-01-01 Epub Date: 2020-11-20
Francesca Agobe, Lisa A DeLouise
{"title":"细胞外小泡在皮肤中的作用及其与纳米颗粒的相互作用。","authors":"Francesca Agobe, Lisa A DeLouise","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin. The role of EVs and their contents including RNA, proteins, and signaling molecules, depends on the specific cells and organs from which they are derived and diseased state. EVs play a key role in cell-to-cell communication. Although the role of EVs in skin biology is a developing field, recent literature suggests they play an important role in skin homeostasis, disease, and transdermal drug delivery. EVs have been shown to modulate skin pigmentation, and aid in the cutaneous wound healing process and the secretion of nanoparticles. This paper reviews the basics of EV biogenesis, their isolation and their role in skin. We also review what is currently known about how nanoparticles may impact the contents of EVs in the skin.</p>","PeriodicalId":519994,"journal":{"name":"World journal of nanoscience and nanotechnology","volume":"1 1","pages":"17-21"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265537/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles.\",\"authors\":\"Francesca Agobe, Lisa A DeLouise\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin. The role of EVs and their contents including RNA, proteins, and signaling molecules, depends on the specific cells and organs from which they are derived and diseased state. EVs play a key role in cell-to-cell communication. Although the role of EVs in skin biology is a developing field, recent literature suggests they play an important role in skin homeostasis, disease, and transdermal drug delivery. EVs have been shown to modulate skin pigmentation, and aid in the cutaneous wound healing process and the secretion of nanoparticles. This paper reviews the basics of EV biogenesis, their isolation and their role in skin. We also review what is currently known about how nanoparticles may impact the contents of EVs in the skin.</p>\",\"PeriodicalId\":519994,\"journal\":{\"name\":\"World journal of nanoscience and nanotechnology\",\"volume\":\"1 1\",\"pages\":\"17-21\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265537/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of nanoscience and nanotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/11/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of nanoscience and nanotechnology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/11/20 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

细胞外囊泡(EVs)包括外泌体和微囊泡。在生理和病理条件下,它们都会从细胞中释放出来。EV可从血浆、唾液和皮肤等多种生物介质中分离出来。EVs 及其内容物(包括 RNA、蛋白质和信号分子)的作用取决于其来源的特定细胞和器官以及疾病状态。EVs 在细胞间通信中发挥着关键作用。虽然 EVs 在皮肤生物学中的作用是一个不断发展的领域,但最近的文献表明,它们在皮肤稳态、疾病和透皮给药中发挥着重要作用。研究表明,EVs 可调节皮肤色素沉着,并有助于皮肤伤口愈合过程和纳米颗粒的分泌。本文回顾了 EV 生物发生的基本原理、EV 的分离及其在皮肤中的作用。我们还回顾了目前已知的纳米粒子如何影响皮肤中的 EVs 内容。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles.

Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin. The role of EVs and their contents including RNA, proteins, and signaling molecules, depends on the specific cells and organs from which they are derived and diseased state. EVs play a key role in cell-to-cell communication. Although the role of EVs in skin biology is a developing field, recent literature suggests they play an important role in skin homeostasis, disease, and transdermal drug delivery. EVs have been shown to modulate skin pigmentation, and aid in the cutaneous wound healing process and the secretion of nanoparticles. This paper reviews the basics of EV biogenesis, their isolation and their role in skin. We also review what is currently known about how nanoparticles may impact the contents of EVs in the skin.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信