非选择性β-受体阻滞剂在难治性腹水肝硬化患者中的应用:我们在哪里?

Q2 Medicine
Arquivos de Gastroenterologia Pub Date : 2024-07-19 eCollection Date: 2024-01-01 DOI:10.1590/S0004-2803.24612023157
Athina Gomes Maia, Luiz Felipe Nunes Palhares, Irina Gomes Maia, Paulo Daniel Medeiros Braulino, Leila Maria Moreira Beltrão Pereira
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引用次数: 0

摘要

背景:非选择性β-受体阻滞剂(NSBB)在食管静脉曲张一级和二级预防中的既定用途最近在利尿剂难治性腹水患者亚群中受到质疑:批判性地分析相关证据,以帮助临床决策:在 Pubmed® 和 Scielo® 数据库中进行了文献综述。独立研究人员共阅读了 2010 年至 2023 年间的 20 篇文章:结论:对于难治性腹水的肝硬化患者来说,使用非苯并噻唑类药物是否有害仍然存在疑问,但我们通过文献综述得出结论,此类患者不应禁用此类药物。相反,医生和患者根据耐受性和血液动力学参数做出决定似乎是一种安全的做法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
NON-SELECTIVE BETA-BLOCKERS IN CIRRHOTIC PATIENTS WITH REFRACTORY ASCITES: WHERE ARE WE?

Background: The established use of non-selective beta-blockers (NSBB) in the primary and secondary prevention of esophageal varices has recently been questioned in the subgroup of patients with diuretic-refractory ascites.

Objective: Critically analyze the body of evidence on the topic in order to assist clinical decisions.

Methods: A literature review was carried out in the Pubmed® and Scielo® databases. In total, 20 articles between 2010 and 2023 were read by independent researchers.

Conclusion: It remains doubtful whether the use of NSBB is deleterious in cirrhotic patients with refractory ascites, however our literature review allows us to conclude that these drugs should not be proscribed in these patients. On the contrary, a doctor-patient decision based on tolerability and hemodynamic parameters certainly seems to be a safe conduct.

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来源期刊
Arquivos de Gastroenterologia
Arquivos de Gastroenterologia Medicine-Gastroenterology
CiteScore
2.00
自引率
0.00%
发文量
109
审稿时长
9 weeks
期刊介绍: The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.
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