DNA-PKcs 超越 DNA 修复的秘密。

IF 6.8 1区医学 Q1 ONCOLOGY

NPJ Precision Oncology Pub Date : 2024-07-23 DOI:10.1038/s41698-024-00655-1

Sydney Camfield, Sayan Chakraborty, Shailendra Kumar Dhar Dwivedi, Pijush Kanti Pramanik, Priyabrata Mukherjee, Resham Bhattacharya

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引用次数: 0

摘要

DNA依赖性蛋白激酶催化亚基（DNA-PKcs）在修复DNA双链断裂中的典型作用，以及在多种恶性肿瘤中的失调报道，推动了作为治疗药物的DNA-PKcs抑制剂的开发。然而，直到最近，DNA-PKcs 与肿瘤发生之间的关系仍主要研究其在非同源末端连接（NHEJ）修复中的作用。新的研究发现，DNA-PKcs 的非经典功能涉及转录调控、端粒维护、代谢调控和免疫信号转导，所有这些功能也可能影响肿瘤的发生。本综述主要讨论 DNA-PKcs 在细胞生物学中的这些非规范作用及其对肿瘤发生的潜在贡献，并评估以 DNA-PKcs 为靶点进行癌症治疗的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Secrets of DNA-PKcs beyond DNA repair

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Secrets of DNA-PKcs beyond DNA repair

The canonical role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in repairing DNA double-strand breaks combined with its reported dysregulation in several malignancies has driven the development of DNA-PKcs inhibitors as therapeutics. However, until recently the relationship between DNA-PKcs and tumorigenesis has been primarily investigated with regard to its role in non-homologous end joining (NHEJ) repair. Emerging research has uncovered non-canonical DNA-PKcs functions involved with transcriptional regulation, telomere maintenance, metabolic regulation, and immune signaling all of which may also impinge on tumorigenesis. This review mainly discusses these non-canonical roles of DNA-PKcs in cellular biology and their potential contribution to tumorigenesis, as well as evaluating the implications of targeting DNA-PKcs for cancer therapy.

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来源期刊

NPJ Precision Oncology ONCOLOGY-

CiteScore

9.90

自引率

1.30%

发文量

审稿时长

18 weeks

期刊介绍： Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.