蛋白精氨酸甲基转移酶:心血管和代谢性疾病的新靶点。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2024-07-01 Epub Date: 2024-07-24 DOI:10.4093/dmj.2023.0362
Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
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引用次数: 0

摘要

心血管疾病(CVDs)和代谢紊乱是严峻的挑战,对患者的临床疗效和生活质量产生了重大影响。要开发有效的治疗策略,就必须深入了解其潜在机制。蛋白质精氨酸甲基转移酶(PRMTs)是一类负责精确调控蛋白质甲基化的酶,在这些疾病的内在病理生理学中发挥着举足轻重的作用,并成为关键的调控因子。在此,我们回顾了最近的研究进展,这些研究阐明了 PRMTs 在心血管系统和代谢性疾病中的多方面参与,大大加深了我们对这些疾病的发病机制和进展的理解。此外,这篇综述还提供了全面的分析,揭示了 PRMTs 在心血管疾病和代谢性疾病所涉及的不同细胞类型中的独特作用,这为揭示针对 PRMTs 的新型治疗干预措施提供了巨大的潜力,从而为有效应对心血管疾病和代谢性疾病给全球带来的巨大负担提供了广阔的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease.

Cardiovascular diseases (CVDs) and metabolic disorders stand as formidable challenges that significantly impact the clinical outcomes and living quality for afflicted individuals. An intricate comprehension of the underlying mechanisms is paramount for the development of efficacious therapeutic strategies. Protein arginine methyltransferases (PRMTs), a class of enzymes responsible for the precise regulation of protein methylation, have ascended to pivotal roles and emerged as crucial regulators within the intrinsic pathophysiology of these diseases. Herein, we review recent advancements in research elucidating on the multifaceted involvements of PRMTs in cardiovascular system and metabolic diseases, contributing significantly to deepen our understanding of the pathogenesis and progression of these maladies. In addition, this review provides a comprehensive analysis to unveil the distinctive roles of PRMTs across diverse cell types implicated in cardiovascular and metabolic disorders, which holds great potential to reveal novel therapeutic interventions targeting PRMTs, thus presenting promising perspectives to effectively address the substantial global burden imposed by CVDs and metabolic disorders.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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