肺栓塞患者凝血酶生成减少与凝血酶生成生物标志物和血细胞指标增加有关

IF 2.3 4区 医学 Q2 HEMATOLOGY
Fakiha Siddiqui, Alfonso Tafur, Amir Darki, Bulent Kantarcioglu, Debra Hoppensteadt, Emily Krupa, Omer Iqbal, Jawed Fareed, Manuel Monreal
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引用次数: 0

摘要

肺栓塞(PE)是一种临床表现各异的异质性疾病。凝血酶生成潜能(TGP)和生物标志物以及血细胞指数可以反映 PE 的潜在病理生理学和风险分层。这项病例对照研究分析了洛约拉大学肺栓塞反应小组项目中 209 名 PE 患者的 TGP,并与正常人血浆(NHP)对照组进行了比较。本研究根据欧洲心脏病学会(ESC)指南,评估了与 PE 严重程度相关的 TGP、生物标志物和细胞指数。统计分析包括中位数和四分位数间距(IQR)、双尾Wilcoxon Mann-Whitney检验、Chi-square检验和Spearman相关分析。共有 209 名 PE 患者,男女比例几乎相等,中位年龄为 63 岁。与对照组相比,观察到 PE 患者的凝血酶峰值和内源性凝血酶潜能(ETP)显著下降,滞后时间显著上升。生物标志物分析显示了明显的升高,其中 D-二聚体的升高最为显著。PE 患者的血细胞指数也有所上升,这与疾病的严重程度有关。PE 严重程度与较高的 TGP 和生物标志物水平相关。不同风险类别的死亡率差异很大,细胞指数升高的患者死亡率最高。TGP和生物标志物与PE严重程度密切相关,有助于进行风险分层。细胞指数升高与死亡率增加有关,突出了其作为预后标志物的潜力。这些发现可提高 PE 管理策略的精确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decreased Thrombin Generation is Associated with Increased Thrombin Generation Biomarkers and Blood Cellular Indices in Pulmonary Embolism.

Pulmonary embolism (PE) is a heterogenous condition with variable clinical presentations. Thrombin generation potential (TGP) and biomarkers, and blood cellular indices can reflect the underlying pathophysiology and risk stratification of PE. This case-control study analyzed TGP in 209 PE patients from Loyola University, Pulmonary Embolism Response Team program compared to normal human plasma (NHP) controls. The present study evaluates TGP and biomarkers, and cellular indices in relation to PE severity, according to the European Society of Cardiology (ESC) guidelines. Statistical analysis including median with interquartile range (IQR), 2-tailed Wilcoxon Mann-Whitney test, Chi-square test, and Spearman Correlational analysis were performed. There were 209 patients with PE, with an almost equal distribution between sex, and a median age of 63 years. Significant downregulation in peak thrombin and endogenous thrombin potential (ETP), as well as upregulation in lag time, were observed in PE patients versus controls. Biomarker analysis revealed pronounced elevations, with D-dimer demonstrating the most significant increase. Blood cellular indices also rose in PE patients, correlating with disease severity. PE severity was associated with higher TGP and biomarker levels. Mortality rates differed significantly across risk categories and were highest in patients with elevated cellular indices. TGP and biomarkers are intricately linked to PE severity and can aid in risk stratification. Elevated cellular indices are associated with increased mortality, highlighting their potential as prognostic markers. These findings could enhance the precision of PE management strategies.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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