努力去除系统性脂褐素

Rejuvenation research Pub Date : 2024-10-01 Epub Date: 2024-08-07 DOI:10.1089/rej.2024.0034
Michael Renteln
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引用次数: 0

摘要

脂褐素是一种难以消化的垃圾,随着年龄的增长会在有丝分裂后细胞的自噬泡和细胞膜中积累。布伦克博士和特曼博士推测,脂褐素的积累是衰老的主要或至少是主要的驱动因素。他们甚至认为,记忆的进化是我们产生脂褐素的原因,因为稳定的突触连接必须长期保持,这意味着神经元的体部也必须保持在同一位置。换句话说,它们无法通过细胞分裂来稀释垃圾。从机理上讲,他们的立场当然是有道理的,因为使有丝分裂后细胞的大部分溶酶体失去作用几乎肯定会对该细胞和周围的微环境产生负面影响。脂褐质积累可能是目前与年龄相关疾病的主要问题。目前,原位降解可能是一项难以完成的任务。不过,本文讨论了一种系统性去除脂褐质的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toward Systemic Lipofuscin Removal.

Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of postmitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor in aging. They even posited that the evolution of memory is the reason why we get lipofuscin at all, as stable synaptic connections must be maintained over time, meaning that the somas of neurons must also remain in the same locale. In other words, they cannot dilute out their garbage over time through cell division. Mechanistically, their position certainly makes sense given that rendering a large percentage of a postmitotic cell's lysosomes useless must almost certainly negatively affect that cell and the surrounding microenvironment. It may be the case that lipofuscin accumulation is the main issue with regard to current age-related disease. Degradation in situ may be an insurmountable task currently. However, a method of systemic lipofuscin removal is discussed herein.

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