肥胖与青春期血清中 11-氧雄激素浓度的增加有关。

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Friederike Wagner, Robert Zeidler, Uta Ceglarek, Wieland Kiess, Jürgen Kratzsch, Alexander Gaudl, Ronald Biemann, Mandy Vogel
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引用次数: 0

摘要

导言:虽然各种因素对儿童和青少年体内经典雄激素合成的影响及其对青春期的影响已得到广泛研究,但关于超重和肥胖与肾上腺衍生的 11 氧合雄激素(11-OA)血清水平合成的关系,似乎存在空白和相互矛盾的研究结果。通过这项研究,我们旨在研究超重和肥胖如何影响大量儿童和青少年青春期的 11-OA 血清水平:我们的队列由 1,054 名 6 至 19 岁的健康儿童组成,他们在 1,734 次就诊中提供了血清样本。采用液相色谱-串联质谱法对 11-酮睾酮 (11-KT)、11-酮雄烯二酮 (11-KA4)、11-ß-羟基睾酮 (11-OHT)、11-ß-羟基雄烯二酮 (11-OHA4)、睾酮、雄二酮和 DHEAS 进行定量分析。此外,我们还评估了 BMI-SDS、皮褶厚度和坦纳分期。显著性水平α设定为α=0.05:结果:在青春期,男孩和女孩的 11-KT、11-KA4、11-OHT 和 11-OHA4 水平都有所上升。在 13 岁及以下的男孩中,11-KT(ß=0.2,p<0.001)、11-KA4(ß=0.16,p<0.001)和 11-OHA4(ß=0.12,p=0.003)与体重指数呈正相关。11-KT(ß=0.1,p=0.047)与 11 岁及以下女孩的体重指数呈正相关。11-OHT 与体重指数呈正相关,与年龄无关(13 岁及以下男孩:ß=0.17, p<0.001; 13 岁以上:ß=0.14,p=0.001;11 岁及以下女孩:ß=0.17,p<0.001:ß=0.17,p<0.001;11 岁以上:ß=0.18, p<0.001).Conclusion:我们发现11-OA的血清水平在所有坦纳阶段都在上升。11-OA与体重指数和皮褶厚度相关,这表明超重和肥胖可能与青春期11-OA血清水平的变化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Obesity Is Associated with Increased 11-Oxyandrogen Serum Concentrations during Puberty.

Introduction: While the influence of various factors on classical androgen synthesis in children and adolescents and its impact on puberty has been widely investigated, there appear to be gaps and contradictory findings regarding the association of overweight and obesity with the synthesis of adrenal-derived 11-oxygenated androgen (11-OA) serum levels. With this study, we aimed to examine how overweight and obesity affect 11-OA serum levels during puberty in a large cohort of children and adolescents.

Methods: Our cohort comprised 1,054 healthy children aged 6-19 years providing serum samples at a total of 1,734 visits. Liquid chromatography-tandem mass spectrometry was used to quantify 11-ketotestosterone (11-KT), 11-ketoandrostendione (11-KA4), 11-β-hydroxytestosterone (11-OHT), 11-β-hydroxyandrostendione (11-OHA4), testosterone, androstenedione, and DHEAS. In addition, we assessed BMI-SDSs, skinfold thicknesses, and Tanner stages. The significance level α was set to α = 0.05.

Results: Increases in 11-KT, 11-KA4, 11-OHT, and 11-OHA4 levels were observed in boys and girls during puberty. 11-KT (β = 0.2, p < 0.001), 11-KA4 (β = 0.16, p < 0.001), and 11-OHA4 (β = 0.12, p = 0.003) were positively correlated with BMI in boys aged 13 years and under. 11-KT (β = 0.1, p = 0.047) was positively correlated with BMI in girls aged 11 years and under. 11-OHT was positively correlated with BMI independent of age (boys 13 years and under: β = 0.17, p < 0.001; over 13 years: β = 0.14, p = 0.001; girls 11 years and under: β = 0.17, p < 0.001; over 11 years: β = 0.18, p < 0.001).

Conclusion: We found increasing 11-OA serum levels throughout all Tanner stages. 11-OAs were observed to be associated with BMI and skinfold thickness, suggesting that overweight and obesity may be associated with pubertal alterations in 11-OA serum levels.

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来源期刊
Hormone Research in Paediatrics
Hormone Research in Paediatrics ENDOCRINOLOGY & METABOLISM-PEDIATRICS
CiteScore
4.90
自引率
6.20%
发文量
88
审稿时长
4-8 weeks
期刊介绍: The mission of ''Hormone Research in Paediatrics'' is to improve the care of children with endocrine disorders by promoting basic and clinical knowledge. The journal facilitates the dissemination of information through original papers, mini reviews, clinical guidelines and papers on novel insights from clinical practice. Periodic editorials from outstanding paediatric endocrinologists address the main published novelties by critically reviewing the major strengths and weaknesses of the studies.
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