Kun Zhang, Daoxin Wang, Shuangquan Wu, Chengeng Wang, Zhengguang Yu, Lei Zhang
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引用次数: 0
摘要
基于模板辅助环缩合程序,合成了两种具有 "拉索型 "结构的希夫碱大环单核镧系配合物(Pr-2l 和 Nd-2l)。根据 X 射线结构分析,两种配合物中的中心十配位镧系离子(Pr3+ 和 Nd3+)具有扭曲的双帽方形反棱柱几何结构,该几何结构被 23 元大环平面两侧的两个轴向螯合硝酸盐和大环骨架中的六个供体完全包围。复合物 Pr-2l 具有较高的相对抑制率,可对 MIC 值(7.81 和 3.91 μg-mL-1)较低的白僵菌和 MRSA 显示出显著的抗菌活性,而复合物 Nd-2l 则对金黄色葡萄球菌、白僵菌和 MRSA 显示出良好的抗菌活性,其 MIC 值分别为 1.95、7.81 和 3.91 μg-mL-1。目前的这项工作相信会为利用希夫碱和镧系元素抗菌片段进一步构建新型抗菌材料提供另一种实用方法。
Template syntheses, molecular structures, and antimicrobial activities of two novel Schiff-base macrocyclic lanthanide complexes
Based on the template-assisted cyclocondensation procedure, two Schiff-base macrocyclic mononuclear lanthanide complexes (Pr-2l and Nd-2l) with the “lasso-type” architecture have been synthesized. According to X-ray structure analysis, the central ten-coordinate lanthanide ions (Pr3+ and Nd3+) in two complexes have distorted bicapped square antiprism geometry, and this geometry is completely encircled by two axial chelating nitrates on each side of the 23-membered macrocyclic plane and six donors in the macrocyclic skeleton. With the higher relatively inhibitory rates, the complex Pr-2l can show significant antimicrobial activities against C. albicans and MRSA with lower MIC values (7.81 and 3.91 μg·mL−1), while complex Nd-2l exhibited good antimicrobial activities for S. aureus, C. albicans, and MRSA whose MIC values are 1.95, 7.81, and 3.91 μg·mL−1. This current work is believed to provide another practical approach to further construct new antimicrobial materials by the use of Schiff-base and lanthanide antimicrobial fragments.
期刊介绍:
Structural Chemistry is an international forum for the publication of peer-reviewed original research papers that cover the condensed and gaseous states of matter and involve numerous techniques for the determination of structure and energetics, their results, and the conclusions derived from these studies. The journal overcomes the unnatural separation in the current literature among the areas of structure determination, energetics, and applications, as well as builds a bridge to other chemical disciplines. Ist comprehensive coverage encompasses broad discussion of results, observation of relationships among various properties, and the description and application of structure and energy information in all domains of chemistry.
We welcome the broadest range of accounts of research in structural chemistry involving the discussion of methodologies and structures,experimental, theoretical, and computational, and their combinations. We encourage discussions of structural information collected for their chemicaland biological significance.