利用 HPLC-MS/MS 筛选并同时测定食品中的 80 种兽药残留

IF 0.9 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Inorganic Materials Pub Date : 2024-07-19 DOI:10.1134/s0020168524700080

V. G. Amelin, I. V. Batov, O. I. Lavrukhina, A. V. Tretyakov, L. K. Kish

{"title":"利用 HPLC-MS/MS 筛选并同时测定食品中的 80 种兽药残留","authors":"V. G. Amelin, I. V. Batov, O. I. Lavrukhina, A. V. Tretyakov, L. K. Kish","doi":"10.1134/s0020168524700080","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A fast method of screening of samples and determination of 80 veterinary drug residues in food safety assessment is proposed. The stage of solid-phase extraction for the purification of the extract in the sample preparation is excluded; here, the matrix effect is neutralized by using isotope-labeled standards. The application of the isotope dilution method makes it possible to exclude the stage of construction of matrix calibration curves and to calculate the concentrations using correction coefficients found from standard aqueous solutions of analytes with a limited number of isotope-labeled standards (one standard each for each class of compounds under determination). The limits of detection of medicinal products (<i>c</i><sub>min</sub> = 0.1–10 ng/g) make it possible to determine their residues at the level of maximum allowable concentrations for food.</p>","PeriodicalId":585,"journal":{"name":"Inorganic Materials","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Screening and Simultaneous Determination of 80 Veterinary Drug Residues in Food by HPLC-MS/MS\",\"authors\":\"V. G. Amelin, I. V. Batov, O. I. Lavrukhina, A. V. Tretyakov, L. K. Kish\",\"doi\":\"10.1134/s0020168524700080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>A fast method of screening of samples and determination of 80 veterinary drug residues in food safety assessment is proposed. The stage of solid-phase extraction for the purification of the extract in the sample preparation is excluded; here, the matrix effect is neutralized by using isotope-labeled standards. The application of the isotope dilution method makes it possible to exclude the stage of construction of matrix calibration curves and to calculate the concentrations using correction coefficients found from standard aqueous solutions of analytes with a limited number of isotope-labeled standards (one standard each for each class of compounds under determination). The limits of detection of medicinal products (<i>c</i><sub>min</sub> = 0.1–10 ng/g) make it possible to determine their residues at the level of maximum allowable concentrations for food.</p>\",\"PeriodicalId\":585,\"journal\":{\"name\":\"Inorganic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-07-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganic Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1134/s0020168524700080\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1134/s0020168524700080","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

摘要提出了一种在食品安全评估中筛选样品和测定 80 种兽药残留的快速方法。该方法排除了样品制备过程中提取物纯化的固相萃取阶段；使用同位素标记的标准品中和了基质效应。采用同位素稀释法可以省去构建基质校准曲线的阶段，只需使用一定数量的同位素标记标准品（每类待测化合物各一个标准品），利用分析物标准水溶液的校正系数计算浓度。药用产品的检测限（cmin = 0.1-10 ng/g）使我们可以在食品最大允许浓度水平上确定其残留量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Screening and Simultaneous Determination of 80 Veterinary Drug Residues in Food by HPLC-MS/MS

查看原文本刊更多论文

Screening and Simultaneous Determination of 80 Veterinary Drug Residues in Food by HPLC-MS/MS

Abstract

A fast method of screening of samples and determination of 80 veterinary drug residues in food safety assessment is proposed. The stage of solid-phase extraction for the purification of the extract in the sample preparation is excluded; here, the matrix effect is neutralized by using isotope-labeled standards. The application of the isotope dilution method makes it possible to exclude the stage of construction of matrix calibration curves and to calculate the concentrations using correction coefficients found from standard aqueous solutions of analytes with a limited number of isotope-labeled standards (one standard each for each class of compounds under determination). The limits of detection of medicinal products (c_min = 0.1–10 ng/g) make it possible to determine their residues at the level of maximum allowable concentrations for food.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Inorganic Materials 工程技术-材料科学：综合

CiteScore

1.40

自引率

25.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Inorganic Materials is a journal that publishes reviews and original articles devoted to chemistry, physics, and applications of various inorganic materials including high-purity substances and materials. The journal discusses phase equilibria, including P–T–X diagrams, and the fundamentals of inorganic materials science, which determines preparatory conditions for compounds of various compositions with specified deviations from stoichiometry. Inorganic Materials is a multidisciplinary journal covering all classes of inorganic materials. The journal welcomes manuscripts from all countries in the English or Russian language.