(-)-呋喃酮的新脱苯类似物：从 l-木糖优化合成

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-07-18 DOI:10.1055/a-2352-9691

Sladjana Stanisavljević, Mirjana Popsavin, Vesna Kojić, Goran Benedeković, Velimir Popsavin, Bojana Srećo Zelenović

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引用次数: 0

摘要

含有高含氧呋喃呋喃酮片段的天然产物以其强大的生物活性而闻名，但其总合成也具有挑战性。本研究完成了五种新型去苯基(-)-呋喃酮类似物的合成，并评估了它们对八种恶性细胞系和一种正常人细胞系的细胞毒活性。与以往类似类似物的合成相比，该合成从 l-木糖开始，从而提高了产率并减少了三种不同中间体的合成步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New Dephenylated Analogues of (–)-Goniofufurone: Optimization of Synthesis from l-Xylose

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New Dephenylated Analogues of (–)-Goniofufurone: Optimization of Synthesis from l-Xylose

Natural products containing highly oxygenated furanofuranone fragments are known for their potent biological activity, but also for their challenging total synthesis. In this study, the synthesis of five novel dephenylated (–)-goniofufurone analogues was completed and their cytotoxic activity against eight malignant and one normal human cell line was evaluated. Compared with previous syntheses of similar analogues, the synthesis was carried out starting from l-xylose, resulting in improved yields and a reduced number of synthetic steps for three divergent intermediates.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.